Tomoya Nakamachi

2025

Regulation of Branchial Anoctamin 1 Expression in Freshwater- and Seawater-Acclimated Japanese Medaka, Oryzias latipes

Konno, N., Togashi, A., Miyanishi, H., Azuma, M., Nakamachi, T. & Matsuda, K., 2025/04, In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 343, 3, p. 356-372 17 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice

Takasaki, I., Nagashima, R., Ueda, T., Ashihara, Y., Nakamachi, T., Okada, T., Toyooka, N., Miyata, A. & Kurihara, T., 2025/02, In: Journal of Pain. 27, 104751.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2024

Intraperitoneal administration of arginine vasotocin (AVT) induces anorexigenic and anxiogenic actions via the brain V1a receptor-signaling pathway in the tiger puffer, Takifugu rubripes

Nagamine, R., Konno, N., Nakamachi, T., Matsubara, H. & Matsuda, K., 2024/08, In: Peptides. 178, 171239.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Intraperitoneal administration of α-melanocyte stimulating hormone (α-MSH) suppresses food intake and induces anxiety-like behavior via the brain MC4 receptor-signaling pathway in goldfish

Watanabe, K., Konno, N., Nakamachi, T. & Matsuda, K., 2024/08/02, (印刷前の電子出版) In: Journal of Neuroendocrinology. p. e13435

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2023

Comparative Observation and Analysis of Preference Behavior Based on Three Types of Taxes and Locomotor Activity in the Goldfish, Carassius auratus

Shimizu, K., Watanabe, K., Konno, N., Nakamachi, T. & Matsuda, K., 2023/01/18, In: Zoological Science. 40, 1, p. 1-6 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

2022

Distribution of neuromedin U (NMU)-like immunoreactivity in the goldfish brain, and effect of intracerebroventricular administration of NMU on emotional behavior in goldfish

Matsuda, K., Watanabe, K., Miyagawa, Y., Maruyama, K., Konno, N. & Nakamachi, T., 2022/10, In: Peptides. 156, 170846.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

2021

High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice

Hirai, S., Miwa, H., Tanaka, T., Toriumi, K., Kunii, Y., Shimbo, H., Sakamoto, T., Hino, M., Izumi, R., Nagaoka, A., Yabe, H., Nakamachi, T., Shioda, S., Dan, T., Miyata, T., Nishito, Y., Suzuki, K., Miyashita, M., Tomoda, T. & Hikida, T. & 4 others, Horiuchi, J., Itokawa, M., Arai, M. & Okado, H., 2021/11, In: Science Advances. 7, 46, eabl6077.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus

Watanabe, K., Konno, N., Nakamachi, T. & Matsuda, K., 2021/11, In: Peptides. 145, 170623.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

2020

Effect of intracerebroventricular administration of two molecular forms of sulfated CCK octapeptide on anxiety-like behavior in the zebrafish danio rerio

Matsuda, K., Yoshida, D., Sachuriga, Watanabe, K., Yokobori, E., Konno, N. & Nakamachi, T., 2020/08, In: Peptides. 130, 170330.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

Identification and signaling characterization of four urotensin II receptor subtypes in the western clawed frog, Xenopus tropicalis

Konno, N., Takano, M., Miura, K., Miyazato, M., Nakamachi, T., Matsuda, K. & Kaiya, H., 2020/12/01, In: General and Comparative Endocrinology. 299, 113586.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Lipopolysaccharide (LPS) inhibits ectopic bone formation induced by bone morphogenetic protein-2 and TGF-β1 through IL-1β production

Matsumoto, A., Takami, M., Urano, E., Nakamachi, T., Yoshimura, K., Yamada, A., Suzawa, T., Miyamoto, Y., Baba, K. & Kamijo, R., 2020/03, In: Journal of Oral Biosciences. 62, 1, p. 44-51 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Molecular Identification, Characterization, and Expression Analysis of a Metallothionein Gene from Septifer virgatus

Sakatoku, A., Ishikawa, M., Yamazaki, K., Nakamachi, T., Kamachi, H., Tanaka, D. & Nakamura, S., 2020/08/01, In: Marine Biotechnology. 22, 4, p. 488-497 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

Nguyen, T. T., Kambe, Y., Kurihara, T., Nakamachi, T., Shintani, N., Hashimoto, H. & Miyata, A., 2020/04/01, In: Molecular Neurobiology. 57, 4, p. 2101-2114 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

2019

Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application

Shioda, S., Takenoya, F., Hirabayashi, T., Wada, N., Seki, T., Nonaka, N. & Nakamachi, T., 2019/07/15, In: Journal of Molecular Neuroscience. 68, 3, p. 420-426 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

21 被引用数 (Scopus)

Expression patterns of PACAP and PAC1R genes and anorexigenic action of PACAP1 and PACAP2 in zebrafish

Nakamachi, T., Tanigawa, A., Konno, N., Shioda, S. & Matsuda, K., 2019, In: Frontiers in Endocrinology. 10, APR, 227.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

Intracerebroventricular administration of arginine vasotocin (AVT) induces anorexigenesis and anxiety-like behavior in goldfish

Araishi, K., Watanabe, K., Yamazaki, T., Nakamachi, T. & Matsuda, K., 2019/09, In: Peptides. 119, 170118.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

Intracerebroventricular administration of sulphated cholecystokinin octapeptide induces anxiety-like behaviour in goldfish

Sachuriga, Iinuma, N., Shibata, H., Yoshida, D., Konno, N., Nakamachi, T. & Matsuda, K., 2019/01, In: Journal of Neuroendocrinology. 31, 1, e12667.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Haraguchi, S., Kamata, M., Tokita, T., Tashiro, K. I., Sato, M., Nozaki, M., Okamoto-Katsuyama, M., Shimizu, I., Han, G., Chowdhury, V. S., Lei, X. F., Miyazaki, T., Kim-Kaneyama, J. R., Nakamachi, T., Matsuda, K., Ohtaki, H., Tokumoto, T., Tachibana, T., Miyazaki, A. & Tsutsui, K., 2019/09, In: eLife. 8

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

21 被引用数 (Scopus)

2018

Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain

Nakamachi, T., Kamata, E., Tanigawa, A., Konno, N., Shioda, S. & Matsuda, K., 2018/05, In: Peptides. 103, p. 40-47 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Novel tear secretion system — the effect and the mechanism of PACAP on tear secretion

Nakamachi, T., 2018, In: Folia Pharmacologica Japonica. 151, 6, p. 232-238 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2017

Neuropeptide Y-induced orexigenic action is attenuated by the orexin receptor antagonist in bullfrog larvae

Matsuda, K., Matsumura, K., Shimizu, S. S., Nakamachi, T. & Konno, N., 2017/04/04, In: Frontiers in Neuroscience. 11, APR, 176.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion

Sasaki, S., Watanabe, J., Ohtaki, H., Matsumoto, M., Murai, N., Nakamachi, T., Hannibal, J., Fahrenkrug, J., Hashimoto, H., Watanabe, H., Sueki, H., Honda, K., Miyazaki, A. & Shioda, S., 2017/02/01, In: British Journal of Dermatology. 176, 2, p. 413-422 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

20 被引用数 (Scopus)

2016

PACAP suppresses dry eye signs by stimulating tear secretion

Nakamachi, T., Ohtaki, H., Seki, T., Yofu, S., Kagami, N., Hashimoto, H., Shintani, N., Baba, A., Mark, L., Lanekoff, I., Kiss, P., Farkas, J., Reglodi, D. & Shioda, S., 2016/06/27, In: Nature Communications. 7, 12034.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

95 被引用数 (Scopus)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke

Matsumoto, M., Nakamachi, T., Watanabe, J., Sugiyama, K., Ohtaki, H., Murai, N., Sasaki, S., Xu, Z., Hashimoto, H., Seki, T., Miyazaki, A. & Shioda, S., 2016/06/01, In: Journal of Molecular Neuroscience. 59, 2, p. 270-279 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

34 被引用数 (Scopus)

Pituitary adenylate cyclase-activating polypeptide enhances saliva secretion via direct binding to PACAP receptors of major salivary glands in mice

Matoba, Y., Nonaka, N., Takagi, Y., Imamura, E., Narukawa, M., Nakamachi, T., Shioda, S., Banks, W. A. & Nakamura, M., 2016/09/01, In: Anatomical Record. 299, 9, p. 1293-1299 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish

Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. & Sakamoto, H., 2016/11/29, In: Scientific Reports. 6, 37991.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

32 被引用数 (Scopus)

2015

Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40

Karki, P., Kurihara, T., Nakamachi, T., Watanabe, J., Asada, T., Oyoshi, T., Shioda, S., Yoshimura, M., Arita, K. & Miyata, A., 2015/02/12, In: Molecular Pain. 11, 1, 6.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

37 被引用数 (Scopus)

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Tsumuraya, T., Ohtaki, H., Song, D., Sato, A., Watanabe, J., Hiraizumi, Y., Nakamachi, T., Xu, Z., Dohi, K., Hashimoto, H., Atsumi, T. & Shioda, S., 2015/01/21, In: Journal of Neuroinflammation. 12, 1, 35.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

33 被引用数 (Scopus)

Two-color Dye-swap DNA Microarray approach toward confident gene expression profiling in PMCAO mouse model for ischemia-related and PACAP38-influenced genes

Hori, M., Shibato, J., Nakamachi, T., Rakwal, R., Ogawa, T., Shioda, S. & Numazawa, S., 2015/03/01, In: Genomics Data. 3, p. 148-154 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

Unraveling the Specific Ischemic Core and Penumbra Transcriptome in the Permanent Middle Cerebral Artery Occlusion Mouse Model Brain Treated with the Neuropeptide PACAP38.

寄稿の翻訳タイトル: Unraveling the Specific Ischemic Core and Penumbra Transcriptome in the Permanent Middle Cerebral Artery Occlusion Mouse Model Brain Treated with the Neuropeptide PACAP38.Hori, M., Nakamachi, T., Shibato, J., Rakwal, R., Shioda, S. & Numazawa, S., 2015/01, In: Microarrays (Basel, Switzerland). 4, 1, p. 2-24 23 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Urotensin II upregulates migration and cytokine gene expression in leukocytes of the African clawed frog, Xenopus laevis

Tomiyama, S., Nakamachi, T., Uchiyama, M., Matsuda, K. & Konno, N., 2015/05/05, In: General and Comparative Endocrinology. 216, p. 46-53 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2014

Comparison of Expression and Proliferative Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its Receptors on Human Astrocytoma Cell Lines

Nakamachi, T., Sugiyama, K., Watanabe, J., Imai, N., Kagami, N., Hori, M., Arata, S. & Shioda, S., 2014/11, In: Journal of Molecular Neuroscience. 54, 3, p. 388-394 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

14 被引用数 (Scopus)

Comprehensive analysis of neonatal versus adult unilateral decortication in a mouse model using behavioral, neuroanatomical, and DNA microarray approaches

Yoshikawa, A., Nakamachi, T., Shibato, J., Rakwal, R. & Shioda, S., 2014/12/05, In: International Journal of Molecular Sciences. 15, 12, p. 22492-22517 26 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) in the human testis and in testicular germ cell tumors

Nakamura, K., Nakamachi, T., Endo, K., Ito, K., Machida, T., Oka, T., Hori, M., Ishizaka, K. & Shioda, S., 2014/06, In: Andrologia. 46, 5, p. 465-471 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

30 被引用数 (Scopus)

NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice

Kigawa, Y., Miyazaki, T., Lei, X. F., Nakamachi, T., Oguchi, T., Kim-Kaneyama, J. R., Taniyama, M., Tsunawaki, S., Shioda, S. & Miyazaki, A., 2014/11/01, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 11, p. 2413-2420 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

38 被引用数 (Scopus)

Orexin A enhances food intake in bullfrog larvae

Shimizu, S., Nakamachi, T., Konno, N. & Matsuda, K., 2014/09, In: Peptides. 59, p. 79-82 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus

Nakamachi, T., Shibata, H., Sakashita, A., Iinuma, N., Wada, K., Konno, N. & Matsuda, K., 2014/07, In: Hormones and Behavior. 66, 2, p. 317-323 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

27 被引用数 (Scopus)

PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain

Hori, M., Nakamachi, T., Shibato, J., Rakwal, R., Tsuchida, M., Shioda, S. & Numazawa, S., 2014/09/23, In: International Journal of Molecular Sciences. 15, 9, p. 17014-17034 21 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

19 被引用数 (Scopus)

PACAP Stimulates Functional Recovery after Spinal Cord Injury through Axonal Regeneration

Tsuchida, M., Nakamachi, T., Sugiyama, K., Tsuchikawa, D., Watanabe, J., Hori, M., Yoshikawa, A., Imai, N., Kagami, N., Matkovits, A., Atsumi, T. & Shioda, S., 2014/11, In: Journal of Molecular Neuroscience. 54, 3, p. 380-387 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

28 被引用数 (Scopus)

Suppression of spinal cord injury on human mesenchymal stem/progenitor cells (MSCs) mediated by pituitary adenylate cyclase activating polypeptide (PACAP)

Ohtaki, H., Tsumuraya, T., Sato, A., Xu, Z., Miyamoto, K., Watanabe, J., Nakamachi, T., Hashimoto, H. & Shioda, S., 2014/10, In: Journal of Neuroimmunology. 275, 1-2, p. 166-167 2 p.

研究成果: ジャーナルへの寄稿 › 学術論文

2013

Autocrine effects of neuromedin b stimulate the proliferation of rat primary osteoblasts

Saito, H., Nakamachil, T., Inoue, K., Ikeda, R., Kitamura, K., Minamino, N., Shioda, S. & Miyata, A., 2013/05, In: Journal of Endocrinology. 217, 2, p. 141-150 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

16 被引用数 (Scopus)

Expression and distribution of pituitary adenylate cyclase-activating polypeptide receptor in reactive astrocytes induced by global brain ischemia in mice.

Nakamachi, T., Farkas, J., Kagami, N., Wada, Y., Hori, M., Tsuchikawa, D., Tsuchida, M., Yoshikawa, A., Imai, N., Hosono, T., Atrata, S. & Shioda, S., 2013, In: Unknown Journal. 118, p. 55-59 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse

Arata, S., Nakamachi, T., Onimaru, H., Hashimoto, H. & Shioda, S., 2013/02, In: European Journal of Neuroscience. 37, 3, p. 407-416 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

Low dose of methylmercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells

Watanabe, J., Nakamachi, T., Ohtaki, H., Naganuma, A., Shioda, S. & Nakajo, S., 2013, In: Journal of Toxicological Sciences. 38, 6, p. 931-935 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

24 被引用数 (Scopus)

PACAP attenuates NMDA-induced retinal damage in association with modulation of the microglia/macrophage status into an acquired deactivation subtype

Wada, Y., Nakamachi, T., Endo, K., Seki, T., Ohtaki, H., Tsuchikawa, D., Hori, M., Tsuchida, M., Yoshikawa, A., Matkovits, A., Kagami, N., Imai, N., Fujisaka, S., Usui, I., Tobe, K., Koide, R., Takahashi, H. & Shioda, S., 2013/10, In: Journal of Molecular Neuroscience. 51, 2, p. 493-502 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

46 被引用数 (Scopus)

2012

IL-6 and PACAP receptor expression and localization after global brain ischemia in mice

Nakamachi, T., Tsuchida, M., Kagami, N., Yofu, S., Wada, Y., Hori, M., Tsuchikawa, D., Yoshikawa, A., Imai, N., Nakamura, K., Arata, S. & Shioda, S., 2012/11, In: Journal of Molecular Neuroscience. 48, 3, p. 518-525 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

33 被引用数 (Scopus)

Intranasal administration of PACAP: Uptake by brain and regional brain targeting with cyclodextrins

Nonaka, N., Farr, S. A., Nakamachi, T., Morley, J. E., Nakamura, M., Shioda, S. & Banks, W. A., 2012/08, In: Peptides. 36, 2, p. 168-175 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

59 被引用数 (Scopus)

Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury

Tsuchikawa, D., Nakamachi, T., Tsuchida, M., Wada, Y., Hori, M., Farkas, J., Yoshikawa, A., Kagami, N., Imai, N., Shintani, N., Hashimoto, H., Atsumi, T. & Shioda, S., 2012/11, In: Journal of Molecular Neuroscience. 48, 3, p. 508-517 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

34 被引用数 (Scopus)

R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts

Miyamoto, A., Takami, M., Matsumoto, A., Mochizuki, A., Yamada, T., Tachi, K., Shibuya, I., Nakamachi, T., Shioda, S., Baba, K., Inoue, T., Miyamoto, Y., Yim, M. & Kamijo, R., 2012/05, In: Cytotechnology. 64, 3, p. 331-339 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice

Hori, M., Nakamachi, T., Rakwal, R., Shibato, J., Ogawa, T., Aiuchi, T., Tsuruyama, T., Tamaki, K. & Shioda, S., 2012/11/23, In: Journal of Neuroinflammation. 9, 739.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

33 被引用数 (Scopus)

中町 智哉

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中町智哉