TY - JOUR
T1 - Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application
AU - Shioda, Seiji
AU - Takenoya, Fumiko
AU - Hirabayashi, Takahiro
AU - Wada, Nobuhiro
AU - Seki, Tamotsu
AU - Nonaka, Naoko
AU - Nakamachi, Tomoya
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and its three receptor subtypes are expressed in neural tissues and in the eye, including the retina, cornea, and lacrimal gland. PACAP is known to exert pleiotropic effects on the central nervous system and in eye tissues where it plays important roles in protecting against dry eye. This review provides an overview of current knowledge regarding dry eye symptoms in aged animals and humans and the protective effects, mechanisms of action. In addition, we also refer to the development of a new preventive/therapeutic method by PACAP of dry eye patients.
AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and its three receptor subtypes are expressed in neural tissues and in the eye, including the retina, cornea, and lacrimal gland. PACAP is known to exert pleiotropic effects on the central nervous system and in eye tissues where it plays important roles in protecting against dry eye. This review provides an overview of current knowledge regarding dry eye symptoms in aged animals and humans and the protective effects, mechanisms of action. In addition, we also refer to the development of a new preventive/therapeutic method by PACAP of dry eye patients.
KW - Aging
KW - Dry eye
KW - Neuroprotective function
KW - PACAP
UR - http://www.scopus.com/inward/record.url?scp=85048750246&partnerID=8YFLogxK
U2 - 10.1007/s12031-018-1087-1
DO - 10.1007/s12031-018-1087-1
M3 - 学術論文
C2 - 29931503
AN - SCOPUS:85048750246
SN - 0895-8696
VL - 68
SP - 420
EP - 426
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
IS - 3
ER -