抄録
Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 979-984 |
| ページ数 | 6 |
| ジャーナル | Biological and Pharmaceutical Bulletin |
| 巻 | 41 |
| 号 | 7 |
| DOI | |
| 出版ステータス | 出版済み - 2018 |
ASJC Scopus 主題領域
- 薬理学
- 薬科学