Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p

Yuichi Watanabe, Kosuke Kawaguchi, Naoki Okuyama, Yuri Sugawara, Takayuki Obita, Mineyuki Mizuguchi, Masashi Morita, Tsuneo Imanaka*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

7 被引用数 (Scopus)

抄録

The interaction of Trypanosoma brucei (Tb) Pex5p and its receptor TbPex14p is essential for the translocation of newly synthesized matrix proteins into the glycosome. Here, we reveal that only the third WXXXF/Y motif of TbPex5p is involved in the interaction and that negative charge of the fourth amino acid is important. We suggest that Phe35 and Phe52 of TbPex14p interact with Trp318 and Phe322 in the third motif and that the Lys56 adjacent to Phe35/Phe52 associates with the fourth Glu in the motif to make the complex. This information is expected to be useful for developing anti-trypanosomal drugs.

本文言語英語
ページ(範囲)242-250
ページ数9
ジャーナルFEBS Letters
590
2
DOI
出版ステータス出版済み - 2016/01/01

ASJC Scopus 主題領域

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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