病態制御薬理学研究室

2025

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Tsuneki, H., Maeda, T., Takatsuki, M., Sekine, T., Masui, S., Onishi, K., Takeda, R., Sugiyama, M., Sakurai, T., Yanagisawa, M., Wada, T. & Sasaoka, T., 2025/03, In: PLoS ONE. 20, 3 March, e0320157.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

2024

C-terminal peptide of preproorexin enhances brain-derived neurotrophic factor expression in rat cerebrocortical cells and recognition memory in mice

Tsuneki, H., Honda, K., Sekine, Y., Yahata, K., Yasue, M., Fujishima, M., Takeda, R., Wada, T. & Sasaoka, T., 2024/02/05, In: European Journal of Pharmacology. 964, 176306.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes

Wada, T., Takeda, Y., Okekawa, A., Komatsu, G., Iwasa, Y., Onogi, Y., Takasaki, I., Hamashima, T., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Scientific Reports. 14, 1, 23829.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity

Okekawa, A., Wada, T., Onogi, Y., Takeda, Y., Miyazawa, Y., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Molecular Medicine. 30, 1, 21.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

2023

A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice

Wada, T., Miyazawa, Y., Ikurumi, M., Fuse, K., Okekawa, A., Onogi, Y., Saito, S., Tsuneki, H. & Sasaoka, T., 2023/12, In: Nutrition and Metabolism. 20, 1, 10.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice

Kagawa, S., Tanabe, K., Hiromura, M., Ogawa, K., Koga, T., Maeda, T., Amo-Shiinoki, K., Ochi, H., Ichiki, Y., Fukuyama, S., Suzuki, S., Suizu, N., Ohmine, T., Hamachi, S., Tsuneki, H., Okuya, S., Sasaoka, T., Tanizawa, Y. & Nagashima, F., 2023, In: Frontiers in Pharmacology. 14, 1167934.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice

Tsuneki, H., Sugiyama, M., Sato, K., Ito, H., Nagai, S., Kon, K., Wada, T., Kobayashi, N., Okada, T., Toyooka, N., Kawasaki, M., Ito, T., Otsubo, R., Okuzaki, D., Yasui, T. & Sasaoka, T., 2023/12/15, In: European Journal of Pharmacology. 961, 176190.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

メディカルスタッフの現状と課題：糖尿病チーム医療，資格取得，学会発表，臨床研究，論文投稿，ジェンダー

Sato, A., Kawanami, D., Fujikawa, R., Suganuma, Y., Furuhashi, M., Morino, K., Yamamoto, K., Wada, M., Imachi, H., Okada, Y., Kawasaki, M., Kondo, K., Sasaoka, T., Takahashi, N., Togashi, Y., Nakajima, H., Hashimoto, N., Fujimoto, K., Bessho, R. & Matoba, Y. & 2 others, Miya, A. & Abiko, A., 2023, In: Journal of the Japan Diabetes Society. 66, 1, p. 118-128 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2022

Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Kon, K., Hautala, L. C., Wang, H., Wada, T., Tsuneki, H., Sasaoka, T. & Lehtonen, S., 2022, In: International Journal of Biological Sciences. 18, 5, p. 1852-1864 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

20 被引用数 (Scopus)

Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

Tsuneki, H., Maeda, T., Takata, S., Sugiyama, M., Otsuka, K., Ishizuka, H., Onogi, Y., Tokai, E., Koshida, C., Kon, K., Takasaki, I., Hamashima, T., Sasahara, M., Rudich, A., Koya, D., Sakurai, T., Yanagisawa, M., Yamanaka, A., Wada, T. & Sasaoka, T., 2022/10/18, In: Cell Reports. 41, 3, 111497.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

16 被引用数 (Scopus)

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

Ito, H., Tsuneki, H., Sasaoka, T., Toyooka, N., Matsuo, M. & Yamazaki, M., 2022/02, In: PLoS ONE. 17, 2 February, e0264386.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

13 被引用数 (Scopus)

2021

Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study

Goldstein, N., Tsuneki, H., Bhandarkar, N., Aimaretti, E., Haim, Y., Kon, K., Sato, K., Wada, T., Liberty, I. F., Kirshtein, B., Dukhno, O., Maixner, N., Gepner, Y., Sasaoka, T. & Rudich, A., 2021/11, In: Obesity. 29, 11, p. 1857-1867 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus

Tanaka, T., Wada, T., Uno, K., Ogihara, S., Ie, H., Okekawa, A., Ishikawa, A., Ito, T., Miyazawa, Y., Sameshima, A., Onogi, Y., Tsuneki, H., Sasahara, M., Nakashima, A., Saito, S. & Sasaoka, T., 2021/07, In: Diabetologia. 64, 7, p. 1660-1673 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

Total synthesis of decahydroquinoline poison frog alkaloids ent-cis-195a and cis-211a

Okada, T., Wu, N., Takashima, K., Ishimura, J., Morita, H., Ito, T., Kodama, T., Yamasaki, Y., Akanuma, S. I., Kubo, Y., Hosoya, K. I., Tsuneki, H., Wada, T., Sasaoka, T., Shimizu, T., Sakai, H., Dwoskin, L. P., Hussaini, S. R., Saporito, R. A. & Toyooka, N., 2021/12/01, In: Molecules. 26, 24, 7529.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature

Honoki, H., Yagi, K., Tsuda, S., Wada, T., Enkaku, A., Nakagawa-Yokoyama, M., Kamigishi, M., Shikata, M., Takikawa-Nishiday, A., Fujisaka, S., Chujo, D., Sasaoka, T., Nakashima, A., Saito, S. & Tobe, K., 2021/07, In: Diabetology International. 12, 3, p. 324-329 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

2020

Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway

Nishida, Y., Nawaz, A., Kado, T., Takikawa, A., Igarashi, Y., Onogi, Y., Wada, T., Sasaoka, T., Yamamoto, S., Sasahara, M., Imura, J., Tokuyama, K., Usui, I., Nakagawa, T., Fujisaka, S., Kunimasa, Y. & Tobe, K., 2020/02/01, In: Journal of Cachexia, Sarcopenia and Muscle. 11, 1, p. 241-258 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

125 被引用数 (Scopus)

Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of obese female mice

Ishikawa, A., Wada, T., Nishimura, S., Ito, T., Okekawa, A., Onogi, Y., Watanabe, E., Sameshima, A., Tanaka, T., Tsuneki, H., Saito, S. & Sasaoka, T., 2020, In: PLoS ONE. 15, 4, e0230885.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

33 被引用数 (Scopus)

Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity

Onogi, Y., Wada, T., Okekawa, A., Matsuzawa, T., Watanabe, E., Ikeda, K., Nakano, M., Kitada, M., Koya, D., Tsuneki, H. & Sasaoka, T., 2020/12/01, In: Scientific Reports. 10, 1, 670.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

26 被引用数 (Scopus)

Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity

Watanabe, E., Wada, T., Okekawa, A., Kitamura, F., Komatsu, G., Onogi, Y., Yamamoto, S., Sasahara, M., Kitada, M., Koya, D., Tsuneki, H. & Sasaoka, T., 2020/11/01, In: Angiogenesis. 23, 4, p. 667-684 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

2019

AS1949490, an inhibitor of 5′-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons

Tsuneki, H., Yoshida, H., Okamoto, K., Yamaguchi, M., Endo, K., Nakano, A., Tsuda, M., Toyooka, N., Wada, T. & Sasaoka, T., 2019/05/15, In: European Journal of Pharmacology. 851, p. 69-79 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Chronotherapeutic effect of orexin antagonists on glucose metabolism in diabetic mice

Kon, K., Tsuneki, H., Ito, H., Takemura, Y., Sato, K., Yamazaki, M., Ishii, Y., Sasahara, M., Rudich, A., Maeda, T., Wada, T. & Sasaoka, T., 2019/10, In: Journal of Endocrinology. 243, 1, p. 59-72 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Hofer, D. C., Zirkovits, G., Pelzmann, H. J., Huber, K., Pessentheiner, A. R., Xia, W., Uno, K., Miyazaki, T., Kon, K., Tsuneki, H., Pendl, T., Zoughbi, W. A., Madreiter-Sokolowski, C. T., Trausinger, G., Abdellatif, M., Schoiswohl, G., Schreiber, R., Eisenberg, T., Magnes, C. & Sedej, S. & 9 others, Eckhardt, M., Sasahara, M., Sasaoka, T., Nitta, A., Hoefler, G., Graier, W. F., Kratky, D., Auwerx, J. & Bogner-Strauss, J. G., 2019/12, In: FASEB Journal. 33, 12, p. 13808-13824 17 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

Role of angiogenesis and chronic inflammation in fat hypertrophy in NASH pathology

Wada, T., Tsuneki, H. & Sasaoka, T., 2019, In: Yakugaku Zasshi. 139, 9, p. 1163-1167 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

2018

Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity

Wada, T., Sameshima, A., Yonezawa, R., Morita, M., Sawakawa, K., Tsuneki, H., Sasaoka, T. & Saito, S., 2018/12, In: PLoS ONE. 13, 12, e0209859.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

2017

Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo

Tsuneki, H., Yoshida, H., Endo, K., Mori, N., Hosoh, S., Tsuda, M., Wada, T. & Sasaoka, T., 2017/07/01, In: Diabetes Research and Clinical Practice. 129, p. 62-72 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance

Wada, T., Ishikawa, A., Watanabe, E., Nakamura, Y., Aruga, Y., Hasegawa, H., Onogi, Y., Honda, H., Nagai, Y., Takatsu, K., Ishii, Y., Sasahara, M., Koya, D., Tsuneki, H. & Sasaoka, T., 2017/12/01, In: Journal of Endocrinology. 235, 3, p. 179-191 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

52 被引用数 (Scopus)

PDGFRβ regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity

Onogi, Y., Wada, T., Kamiya, C., Inata, K., Matsuzawa, T., Inaba, Y., Kimura, K., Inoue, H., Yamamoto, S., Ishii, Y., Koya, D., Tsuneki, H., Sasahara, M. & Sasaoka, T., 2017/04/01, In: Diabetes. 66, 4, p. 1008-1021 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

67 被引用数 (Scopus)

2016

Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia

Takikawa, A., Usui, I., Fujisaka, S., Ikutani, M., Senda, S., Hattori, S., Tsuneyama, K., Koshimizu, Y., Inoue, R., Tanaka-Hayashi, A., Nakagawa, T., Nagai, Y., Takatsu, K., Sasaoka, T., Mori, H. & Tobe, K., 2016/03/01, In: Diabetology International. 7, 1, p. 59-68 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., 2016/01, In: Endocrinology. 157, 1, p. 195-206 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

17 被引用数 (Scopus)

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., 2016/11, In: Endocrinology. 157, 11, p. 4146-4157 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

25 被引用数 (Scopus)

2015

Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes

Kato, H., Nagai, Y., Ohta, A., Tenjin, A., Nakamura, Y., Tsukiyama, H., Sasaki, Y., Fukuda, H., Ohshige, T., Terashima, Y., Sada, Y., Kondo, A., Sasaoka, T. & Tanaka, Y., 2015/07/01, In: Diabetes Research and Clinical Practice. 109, 1, p. 199-205 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

54 被引用数 (Scopus)

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., Kimura, K., Inoue, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., 2015/02/01, In: Diabetes. 64, 2, p. 459-470 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

61 被引用数 (Scopus)

Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity

Sameshima, A., Wada, T., Ito, T., Kashimura, A., Sawakawa, K., Yonezawa, R., Tsuneki, H., Ishii, Y., Sasahara, M., Saito, S. & Sasaoka, T., 2015, In: Journal of Endocrinology. 227, 1, p. 25-36 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

2014

Effect of sitagliptin on glycemic control and beta cell function in japanese patients given basal-supported oral therapy for type 2 diabetes

Asai, S., Ohta, A., Kato, H., Sada, Y., Nagai, Y., Kondo, A., Sasaoka, T. & Tanaka, Y., 2014, In: Endocrine Journal. 61, 12, p. 1213-1220 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

2013

Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions

Wada, T., Onogi, Y., Kimura, Y., Nakano, T., Fusanobori, H., Ishii, Y., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2013/05/05, In: European Journal of Pharmacology. 707, 1-3, p. 120-129 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet

Wada, T., Miyashita, Y., Sasaki, M., Aruga, Y., Nakamura, Y., Ishii, Y., Sasahara, M., Kanasaki, K., Kitada, M., Koya, D., Shimano, H., Tsuneki, H. & Sasaoka, T., 2013/12/01, In: American Journal of Physiology - Endocrinology and Metabolism. 305, 11, p. E1415-E1425

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

66 被引用数 (Scopus)

Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice

Tsuneki, H., Tokai, E., Sugawara, C., Wada, T., Sakurai, T. & Sasaoka, T., 2013/06, In: Neuropeptides. 47, 3, p. 213-219 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

31 被引用数 (Scopus)

Impact of divergent effects of astaxanthin on insulin signaling in L6 cells

Ishiki, M., Nishida, Y., Ishibashi, H., Wada, T., Fujisaka, S., Takikawa, A., Urakaze, M., Sasaoka, T., Usui, I. & Tobe, K., 2013/08/01, In: Endocrinology. 154, 8, p. 2600-2612 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

77 被引用数 (Scopus)

Protective effects of coenzyme Q₁₀ against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells

Tsuneki, H., Tokai, E., Suzuki, T., Seki, T., Okubo, K., Wada, T., Okamoto, T., Koya, S., Kimura, I. & Sasaoka, T., 2013/02/15, In: European Journal of Pharmacology. 701, 1-3, p. 218-227 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

32 被引用数 (Scopus)

Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)

Ichihara, Y., Fujimura, R., Tsuneki, H., Wada, T., Okamoto, K., Gouda, H., Hirono, S., Sugimoto, K., Matsuya, Y., Sasaoka, T. & Toyooka, N., 2013/04, In: European Journal of Medicinal Chemistry. 62, p. 649-660 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

SH2-Containing Inositol 5′-Phosphatase 2 Selectively Impairs Hypothalamic Insulin Signalling and Regulation of Food Intake in Mice

Ichihara, Y., Wada, T., Soeda, Y., Ishii, Y., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2013/04, In: Journal of Neuroendocrinology. 25, 4, p. 372-382 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

2012

[Molecular mechanisms of biological action of insulin].

Sasaoka, T., Tsuneki, H. & Wada, T., 2012/05, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 3, p. 145-154 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

[Perspective of new and future treatment of type 2 diabetes].

Sasaoka, T., 2012/05, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 3, p. 707-715 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Blockade of mineralocorticoid receptor ameliorates glucose and lipid metabolism and non-alcoholic steatohepatitis(NASH) developed in liver-specific SREBP1c transgenic mice fed high-fat and high-fructose diet

Sasaoka, T., 2012, In: Therapeutic Research. 33, 6, p. 824-828 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet

Yonezawa, R., Wada, T., Matsumoto, N., Morita, M., Sawakawa, K., Ishii, Y., Sasahara, M., Tsuneki, H., Saito, S. & Sasaoka, T., 2012/08/15, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 4, p. E445-E456

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

81 被引用数 (Scopus)

Intracellular lipid content of liver and skeletal muscle in patients with adult growth hormone deficiency without diabetes mellitus

Sato, T., Katabami, T., Furukawa, K., Narimatsu, H., Hashimoto, T., Nakajima, Y., Ohta, A., Sasaoka, T. & Tanaka, Y., 2012/10, In: Obesity Research and Clinical Practice. 6, 4, p. e321-e329

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

Asano, N., Obatake-Ikeda, K., Higashi, Y., Kaji, A., Kato, A., Adachi, I., Kettawan, A., Okamoto, T., Koya, S., Suzuki, T., Tsuneki, H., Sasaoka, T. & Seki, T., 2012, In: Journal of Traditional Medicines. 29, 3, p. 124-136 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Synthesis and biological activities of the 3,5-disubstituted indolizidine poison frog alkaloid 239Q and its congeners

Wang, X., Tsuneki, H., Urata, N., Tezuka, Y., Wada, T., Sasaoka, T., Sakai, H., Saporito, R. A. & Toyooka, N., 2012/12, In: European Journal of Organic Chemistry. 36, p. 7082-7092 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

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