Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

Naoki Asano; Kyoko Obatake-Ikeda; Yasuhiko Higashi; Akira Kaji; Atsushi Kato; Isao Adachi; Aikkarach Kettawan; Tadashi Okamoto; Sakuji Koya; Takashi Suzuki; Hiroshi Tsuneki; Toshiyasu Sasaoka; Takayuki Seki

doi:10.11339/jtm.29.124

Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

Naoki Asano^*, Kyoko Obatake-Ikeda, Yasuhiko Higashi, Akira Kaji, Atsushi Kato, Isao Adachi, Aikkarach Kettawan, Tadashi Okamoto, Sakuji Koya, Takashi Suzuki, Hiroshi Tsuneki, Toshiyasu Sasaoka, Takayuki Seki

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

抄録

The extract of Sasa kurilentis was found to strongly inhibit ascorbate/Fe²⁺-stimulated formation of thiobarbituric reactive substances, an indicator of lipid peroxidation, in isolated rat liver mitochondoria, and further to protect human embryonic lung (HEL) cells from H₂O₂-induced mitochondrial dysfunction in a dose-dependent manner. Moreover, the Sasa extract effectively prevented the intracellular ROS production in HUVEC exposed to the high concentration (30 mM) of glucose and also greatly inhibited the adhesion of U937 leukemia cells to HUVEC exposed to oxidative stress. Thus, the antioxidative benefits of the Sasa extract observed in the present study may contribute to improve endothelial dysfunction related to hyperglycemia.

本文言語	英語
ページ（範囲）	124-136
ページ数	13
ジャーナル	Journal of Traditional Medicines
巻	29
号	3
DOI	https://doi.org/10.11339/jtm.29.124
出版ステータス	出版済み - 2012

ASJC Scopus 主題領域

創薬
補完代替医療

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10.11339/jtm.29.124

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title = "Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress",

abstract = "The extract of Sasa kurilentis was found to strongly inhibit ascorbate/Fe2+-stimulated formation of thiobarbituric reactive substances, an indicator of lipid peroxidation, in isolated rat liver mitochondoria, and further to protect human embryonic lung (HEL) cells from H2O2-induced mitochondrial dysfunction in a dose-dependent manner. Moreover, the Sasa extract effectively prevented the intracellular ROS production in HUVEC exposed to the high concentration (30 mM) of glucose and also greatly inhibited the adhesion of U937 leukemia cells to HUVEC exposed to oxidative stress. Thus, the antioxidative benefits of the Sasa extract observed in the present study may contribute to improve endothelial dysfunction related to hyperglycemia.",

keywords = "CoQ, ROS production, Sasa kurilentis, endothelial dysfunction, mitochondrial dysfunction, tricin",

author = "Naoki Asano and Kyoko Obatake-Ikeda and Yasuhiko Higashi and Akira Kaji and Atsushi Kato and Isao Adachi and Aikkarach Kettawan and Tadashi Okamoto and Sakuji Koya and Takashi Suzuki and Hiroshi Tsuneki and Toshiyasu Sasaoka and Takayuki Seki",

year = "2012",

doi = "10.11339/jtm.29.124",

language = "英語",

volume = "29",

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T1 - Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

AU - Asano, Naoki

AU - Obatake-Ikeda, Kyoko

AU - Higashi, Yasuhiko

AU - Kaji, Akira

AU - Kato, Atsushi

AU - Adachi, Isao

AU - Kettawan, Aikkarach

AU - Okamoto, Tadashi

AU - Koya, Sakuji

AU - Suzuki, Takashi

AU - Tsuneki, Hiroshi

AU - Sasaoka, Toshiyasu

AU - Seki, Takayuki

PY - 2012

Y1 - 2012

N2 - The extract of Sasa kurilentis was found to strongly inhibit ascorbate/Fe2+-stimulated formation of thiobarbituric reactive substances, an indicator of lipid peroxidation, in isolated rat liver mitochondoria, and further to protect human embryonic lung (HEL) cells from H2O2-induced mitochondrial dysfunction in a dose-dependent manner. Moreover, the Sasa extract effectively prevented the intracellular ROS production in HUVEC exposed to the high concentration (30 mM) of glucose and also greatly inhibited the adhesion of U937 leukemia cells to HUVEC exposed to oxidative stress. Thus, the antioxidative benefits of the Sasa extract observed in the present study may contribute to improve endothelial dysfunction related to hyperglycemia.

AB - The extract of Sasa kurilentis was found to strongly inhibit ascorbate/Fe2+-stimulated formation of thiobarbituric reactive substances, an indicator of lipid peroxidation, in isolated rat liver mitochondoria, and further to protect human embryonic lung (HEL) cells from H2O2-induced mitochondrial dysfunction in a dose-dependent manner. Moreover, the Sasa extract effectively prevented the intracellular ROS production in HUVEC exposed to the high concentration (30 mM) of glucose and also greatly inhibited the adhesion of U937 leukemia cells to HUVEC exposed to oxidative stress. Thus, the antioxidative benefits of the Sasa extract observed in the present study may contribute to improve endothelial dysfunction related to hyperglycemia.

KW - CoQ

KW - ROS production

KW - Sasa kurilentis

KW - endothelial dysfunction

KW - mitochondrial dysfunction

KW - tricin

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U2 - 10.11339/jtm.29.124

DO - 10.11339/jtm.29.124

M3 - 学術論文

AN - SCOPUS:85024468076

SN - 1880-1447

VL - 29

SP - 124

EP - 136

JO - Journal of Traditional Medicines

JF - Journal of Traditional Medicines

IS - 3

ER -

Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

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