和漢医薬学総合研究所研究開発部門複雑系解析分野

2025

Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions

Nozaki, Y., Kobayashi, M., Fukuoh, T., Ishimatsu, M., Narita, T., Taki, K., Hirao, Y., Ayabe, S., Yokoyama, M., Otani, Y., Mizunoe, Y., Matsumoto, M., Ohno, N., Kaifu, T., Okazaki, S., Goitsuka, R., Nakagawa, Y., Shimano, H., Iwakura, Y. & Higami, Y., 2025/12, In: Scientific Reports. 15, 1, 12839.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2024

A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease

Kashiwagi, M., Beck, G., Kanuka, M., Arai, Y., Tanaka, K., Tatsuzawa, C., Koga, Y., Saito, Y. C., Takagi, M., Oishi, Y., Sakaguchi, M., Baba, K., Ikuno, M., Yamakado, H., Takahashi, R., Yanagisawa, M., Murayama, S., Sakurai, T., Sakai, K. & Nakagawa, Y. & 3 others, Watanabe, M., Mochizuki, H. & Hayashi, Y., 2024/10/31, In: Cell. 187, 22, p. 6272-6289.e21

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation

Iyoda, T., Ohishi, A., Wang, Y., Yokoyama, M. S., Kazama, M., Okita, N., Inouye, S., Nakagawa, Y., Shimano, H. & Fukai, F., 2024/02, In: International Journal of Molecular Sciences. 25, 3, 1825.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Ishizawa, M., Fujihara, K., Yachida, J., Ikeda, I., Sato, T., Yamada, T., Kobayashi, A., Tanaka, S., Nakagawa, Y., Matsuzaka, T., Shimano, H., Tashiro, M., Kodama, S., Kato, K. & Sone, H., 2024/02, In: Journal of Bone Metabolism. 31, 1, p. 21-30 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Yanagisawa, A., Kim, J., Naito, A., Kobayashi, T., Misawa, T., Sakao, S., Jujo-Sanada, T., Kawasaki, T., Muroi, S. I., Sasaki, S. I., Suzuki, T., Hayakawa, Y., Nakagawa, Y., Kasuya, Y. & Tatsumi, K., 2024/12, In: Scientific Reports. 14, 1, 27069.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis

Cao, Y., Araki, M., Nakagawa, Y., Deisen, L., Lundsgaard, A., Kanta, J. M., Holm, S., Johann, K., Brings Jacobsen, J. C., Jähnert, M., Schürmann, A., Kiens, B., Clemmensen, C., Shimano, H., Fritzen, A. M. & Kleinert, M., 2024/09, In: Molecular Metabolism. 87, 101991.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia

Furuta, Y., Osaki, Y., Nakagawa, Y., Han, S. I., Araki, M., Shikama, A., Ohuchi, N., Yamazaki, D., Matsuda, E., Nohara, S., Mizunoe, Y., Kainoh, K., Suehara, Y., Ohno, H., Takeuchi, Y., Miyamoto, T., Murayama, Y., Sugano, Y., Iwasaki, H. & Hirano, K. I. & 12 others, Koseki, M., Nakano, S., Tokiwa, H., Sekiya, M., Yahagi, N., Matsuzaka, T., Nakamagoe, K., Tomidokoro, Y., Mitsui, J., Tsuji, S., Suzuki, H. & Shimano, H., 2024, In: Journal of atherosclerosis and thrombosis. 31, 9, p. 1304-1318 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Hepatic ketone body regulation of renal gluconeogenesis

Hatano, R., Lee, E., Sato, H., Kiuchi, M., Hirahara, K., Nakagawa, Y., Shimano, H., Nakayama, T., Tanaka, T. & Miki, T., 2024/06, In: Molecular Metabolism. 84, 101934.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice

Fujisaka, S., Watanabe, Y., Toume, K., Morinaga, Y., Nawaz, A., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Igarashi, Y., Nakagawa, Y. & Tobe, K., 2024/07, In: Diabetology International. 15, 3, p. 495-506 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation

Kamei, K., Yahara, Y., Kim, J.-D., Tsuji, M., Iwasaki, M., Takemori, H., Seki, S., Makino, H., Futakawa, H., Hirokawa, T., Tung, N. T. C., Nakagawa, T. & Kawaguchi, Y., 2024/07/20, In: Journal of Bone and Mineral Research. 39, 9, p. 1340 1355 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages

Diercks, A. H., Podolskaia, I. S., Murray, T. A., Jahn, A. N., Mai, D., Liu, D., Amon, L. M., Nakagawa, Y., Shimano, H., Aderem, A. & Gold, E. S., 2024/08/13, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 33, e2406492121.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca²⁺ Allostasis Toward β-Cell Failure

Motomura, K., Matsuzaka, T., Shichino, S., Ogawa, T., Pan, H., Nakajima, T., Asano, Y., Okayama, T., Takeuchi, T., Ohno, H., Han, S. I., Miyamoto, T., Takeuchi, Y., Sekiya, M., Sone, H., Yahagi, N., Nakagawa, Y., Oda, T., Ueha, S. & Ikeo, K. & 3 others, Ogura, A., Matsushima, K. & Shimano, H., 2024/01, In: Diabetes. 73, 1, p. 75-92 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

2023

ER proteostasis regulators cell-non-autonomously control sleep

Kawano, T., Kashiwagi, M., Kanuka, M., Chen, C. K., Yasugaki, S., Hatori, S., Miyazaki, S., Tanaka, K., Fujita, H., Nakajima, T., Yanagisawa, M., Nakagawa, Y. & Hayashi, Y., 2023/03/28, In: Cell Reports. 42, 3, 112267.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Watanabe, Y., Fujisaka, S., Morinaga, Y., Watanabe, S., Nawaz, A., Hatta, H., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Honda, K., Nakagawa, Y., Softic, S., Hirabayashi, K., Nakagawa, T., Nagai, Y. & Tobe, K., 2023/11, In: Molecular Metabolism. 77, 101797.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

19 被引用数 (Scopus)

Macrophage SREBP1 regulates skeletal muscle regeneration

Oishi, Y., Koike, H., Kumagami, N., Nakagawa, Y., Araki, M., Taketomi, Y., Miki, Y., Matsuda, S., Matsuzaka, T., Ozawa, H., Shimano, H., Murakami, M. & Manabe, I., 2023, In: Frontiers in Immunology. 14, 1251784.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

Saito, K., Sekiya, M., Kainoh, K., Yoshino, R., Hayashi, A., Han, S. I., Araki, M., Ohno, H., Takeuchi, Y., Tsuyuzaki, T., Yamazaki, D., Wanpei, C., Hada, L., Watanabe, S., Paramita Adi Putri, P. I., Murayama, Y., Sugano, Y., Osaki, Y., Iwasaki, H. & Yahagi, N. & 4 others, Suzuki, H., Miyamoto, T., Matsuzaka, T. & Shimano, H., 2023/07, In: Journal of Biological Chemistry. 299, 7, 104890.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

Han, S. I., Nakakuki, M., Nakagawa, Y., Wang, Y., Araki, M., Yamamoto, Y., Tokiwa, H., Takeda, H., Mizunoe, Y., Motomura, K., Ohno, H., Kainoh, K., Murayama, Y., Aita, Y., Takeuchi, Y., Osaki, Y., Miyamoto, T., Sekiya, M., Matsuzaka, T. & Yahagi, N. & 5 others, Sone, H., Daitoku, H., Sato, R., Kawano, H. & Shimano, H., 2023/11/01, In: PNAS nexus. 2, 11, 2.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2022

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease

Araki, M., Nakagawa, Y., Saito, H., Yamada, Y., Han, S. I., Mizunoe, Y., Ohno, H., Miyamoto, T., Sekiya, M., Matsuzaka, T., Sone, H. & Shimano, H., 2022/12, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 323, 6, p. G627-G639

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at rest

寄稿の翻訳タイトル: High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at restYamazaki, R., Matsukiyo, S., Morita, T., Tanaka, S. J., Umeda, T., Aihara, K., Edamoto, M., Egashira, S., Hatsuyama, R., Higuchi, T., Hihara, T., Horie, Y., Hoshino, M., Ishii, A., Ishizaka, N., Itadani, Y., Izumi, T., Kambayashi, S., Kakuchi, S. & Katsuki, N. & 34 others, Kawamura, R., Kawamura, Y., Kisaka, S., Kojima, T., Konuma, A., Kumar, R., Minami, T., Miyata, I., Moritaka, T., Murakami, Y., Nagashima, K., Nakagawa, Y., Nishimoto, T., Nishioka, Y., Ohira, Y., Ohnishi, N., Ota, M., Ozaki, N., Sano, T., Sakai, K., Sei, S., Shiota, J., Shoji, Y., Sugiyama, K., Suzuki, D., Takagi, M., Toda, H., Tomita, S., Tomiya, S., Yoneda, H., Takezaki, T., Tomita, K., Kuramitsu, Y. & Sakawa, Y., 2022/02, In: Physical Review E. 105, p. 10883-

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

Okajima, Y., Matsuzaka, T., Miyazaki, S., Motomura, K., Ohno, H., Sharma, R., Shimura, T., Istiqamah, N., Han, S. I., Mizunoe, Y., Osaki, Y., Iwasaki, H., Yatoh, S., Suzuki, H., Sone, H., Miyamoto, T., Aita, Y., Takeuchi, Y., Sekiya, M. & Yahagi, N. & 3 others, Nakagawa, Y., Tomita, T. & Shimano, H., 2022/04/01, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1868, 4, 166339.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Multi-omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin

Kobayashi, T., Kim, J. D., Naito, A., Yanagisawa, A., Jujo-Sanada, T., Kasuya, Y., Nakagawa, Y., Sakao, S., Tatsumi, K. & Suzuki, T., 2022/05, In: International Journal of Molecular Medicine. 49, 5, 5124.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis

Kodama, S., Fujihara, K., Horikawa, C., Kitazawa, M., Iwanaga, M., Kato, K., Watanabe, K., Nakagawa, Y., Matsuzaka, T., Shimano, H. & Sone, H., 2022/05, In: Journal of Diabetes Investigation. 13, 5, p. 900-908 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

22 被引用数 (Scopus)

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

Yamada, Y., Saito, H., Araki, M., Tsuchimoto, Y., Muroi, S. I., Suzuki, K., Toume, K., Kim, J. D., Matsuzaka, T., Sone, H., Shimano, H. & Nakagawa, Y., 2022/10, In: Nutrients. 14, 19, 3920.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

2021

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency

Cho, K., Ushiki, T., Ishiguro, H., Tamura, S., Araki, M., Suwabe, T., Katagiri, T., Watanabe, M., Fujimoto, Y., Ohashi, R., Ajioka, Y., Shimizu, I., Okuda, S., Masuko, M., Nakagawa, Y., Hirai, H., Alexander, W. S., Shimano, H. & Sone, H., 2021/10/22, In: iScience. 24, 10, 103117.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Dinh, T. T. H., Iseki, H., Mizuno, S., Iijima-Mizuno, S., Tanimoto, Y., Daitoku, Y., Kato, K., Hamada, Y., Hasan, A. S. H., Suzuki, H., Murata, K., Muratani, M., Ema, M., Kim, J. D., Ishida, J., Fukamizu, A., Kato, M., Takahashi, S., Yagami, K. I. & Wilson, V. & 2 others, Arkell, R. M. & Sugiyama, F., 2021/05, In: eLife. 10, e50346.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

Nakagawa, Y., Wang, Y., Han, S. I., Okuda, K., Oishi, A., Yagishita, Y., Kumagai, K., Ohno, H., Osaki, Y., Mizunoe, Y., Araki, M., Murayama, Y., Iwasaki, H., Konishi, M., Itoh, N., Matsuzaka, T., Sone, H., Yamada, N. & Shimano, H., 2021/01, In: CMGH. 11, 4, p. 949-971 23 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

18 被引用数 (Scopus)

Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development

Hashimoto, M., Kumabe, A., Kim, J. D., Murata, K., Sekizar, S., Williams, A., Lu, W., Ishida, J., Nakagawa, T., Endo, M., Minami, Y. & Fukamizu, A., 2021/03, In: Journal of Neurochemistry. 156, 6, p. 834-847 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle

Mizunoe, Y., Kobayashi, M., Saito, H., Goto, A., Migitaka, R., Miura, K., Okita, N., Sudo, Y., Tagawa, R., Yoshida, M., Umemori, A., Nakagawa, Y., Shimano, H. & Higami, Y., 2021/10/15, In: Experimental Gerontology. 154, 111519.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling

Nakagawa, Y., Kumagai, K., Han, S. I., Mizunoe, Y., Araki, M., Mizuno, S., Ohno, H., Matsuo, K., Yamada, Y., Kim, J. D., Miyamoto, T., Sekiya, M., Konishi, M., Itoh, N., Matsuzaka, T., Takahashi, S., Sone, H. & Shimano, H., 2021/06, In: FASEB Journal. 35, 6, e21663.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment

Satou-Kobayashi, Y., Kim, J. D., Fukamizu, A. & Asashima, M., 2021/12, In: Scientific Reports. 11, 1, 14537.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

2020

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Satoh, A., Han, S. I., Araki, M., Nakagawa, Y., Ohno, H., Mizunoe, Y., Kumagai, K., Murayama, Y., Osaki, Y., Iwasaki, H., Sekiya, M., Konishi, M., Itoh, N., Matsuzaka, T., Sone, H. & Shimano, H., 2020/03/27, In: iScience. 23, 3, 100930.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming

Noguchi, K., Ishida, J., Kim, J. D., Muromachi, N., Kako, K., Mizukami, H., Lu, W., Ishimaru, T., Kawasaki, S., Kaneko, S., Usui, J., Ohtsu, H., Yamagata, K. & Fukamizu, A., 2020/02/11, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3150-3156 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

16 被引用数 (Scopus)

Srebp-1c/Fgf21/Pgc-1α axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose tissue

Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H. & Higami, Y., 2020/07, In: Nutrients. 12, 7, p. 1-15 15 p., 2054.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

23 被引用数 (Scopus)

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1

Ma, Y., Sekiya, M., Kainoh, K., Matsuda, T., Iwasaki, H., Osaki, Y., Sugano, Y., Suzuki, H., Takeuchi, Y., Miyamoto, T., Yahagi, N., Nakagawa, Y., Matsuzaka, T. & Shimano, H., 2020/03/05, In: Biochemical and Biophysical Research Communications. 523, 2, p. 354-360 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

Suzuki, K., Kim, J. D., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K. & Kasuya, Y., 2020/08, In: Molecular Medicine Reports. 22, 2, p. 1518-1526 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

Transcriptomic evaluation of pulmonary fibrosis-related genes: Utilization of transgenic mice with modifying p38 signal in the lungs

Matsuda, S., Kim, J. D., Sugiyama, F., Matsuo, Y., Ishida, J., Murata, K., Nakamura, K., Namiki, K., Sudo, T., Kuwaki, T., Hatano, M., Tatsumi, K., Fukamizu, A. & Kasuya, Y., 2020/09/02, In: International Journal of Molecular Sciences. 21, 18, p. 1-17 17 p., 6746.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism

Hoshino, S., Kobayashi, M., Tagawa, R., Konno, R., Abe, T., Furuya, K., Miura, K., Wakasawa, H., Okita, N., Sudo, Y., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Kawabe, H. & Higami, Y., 2020/03/01, In: FEBS Open Bio. 10, 3, p. 306-315 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

13 被引用数 (Scopus)

2019

Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction

Nagano, K., Kwon, C., Ishida, J., Hashimoto, T., Kim, J. D., Kishikawa, N., Murao, M., Kimura, K., Kasuya, Y., Kimura, S., Chen, Y. C., Tsuchimochi, H., Shirai, M., Pearson, J. T. & Fukamizu, A., 2019/11/01, In: Journal of Biochemistry. 166, 5, p. 383-392 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

Dietary protein restriction increases hepatic leptin receptor mRNA and plasma soluble leptin receptor in male rodents

Yamada, R., Odamaki, S., Araki, M., Watanabe, T., Matsuo, K., Uchida, K., Kato, T., Ozaki-Masuzawa, Y. & Takenaka, A., 2019/07/01, In: PLoS ONE. 14, 7, e0219603.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

Qin, R., Murakoshi, N., Xu, D. Z., Tajiri, K., Feng, D., Stujanna, E. N., Yonebayashi, S., Nakagawa, Y., Shimano, H., Nogami, A., Koike, A., Aonuma, K. & Ieda, M., 2019/02, In: Physiological Reports. 7, 4, e13972.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

24 被引用数 (Scopus)

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

Murayama, Y., Yahagi, N., Takeuchi, Y., Aita, Y., Mehrazad Saber, Z., Wada, N., Li, E. X., Piao, X., Sawada, Y., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Izumida, Y., Miyamoto, T., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y. & Iwasaki, H. & 6 others, Kobayashi, K., Yatoh, S., Suzuki, H., Yagyu, H., Kawakami, Y. & Shimano, H., 2019/02, In: FEBS Letters. 593, 4, p. 423-432 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

29 被引用数 (Scopus)

KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts

Mizukami, H., Kim, J. D., Tabara, S., Lu, W., Kwon, C., Nakashima, M. & Fukamizu, A., 2019/04/01, In: Journal of Biochemistry. 165, 4, p. 335-342 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

22 被引用数 (Scopus)

The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation

Lu, W., Kim, J. D., Tabara, S., Kwon, C., Mizukami, H., Kimura, K. & Fukamizu, A., 2019/07/05, In: Biochemical and Biophysical Research Communications. 514, 4, p. 1185-1191 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2018

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes

Piao, X., Yahagi, N., Takeuchi, Y., Aita, Y., Murayama, Y., Sawada, Y., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Izumida, Y., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y., Iwasaki, H., Kobayashi, K., Yatoh, S., Suzuki, H. & Yagyu, H. & 2 others, Kawakami, Y. & Shimano, H., 2018/02, In: FEBS Letters. 592, 3, p. 422-433 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

Yuan, X., Tsujimoto, K., Hashimoto, K., Kawahori, K., Hanzawa, N., Hamaguchi, M., Seki, T., Nawa, M., Ehara, T., Kitamura, Y., Hatada, I., Konishi, M., Itoh, N., Nakagawa, Y., Shimano, H., Takai-Igarashi, T., Kamei, Y. & Ogawa, Y., 2018/12/01, In: Nature Communications. 9, 1, 636.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

70 被引用数 (Scopus)

Gestational changes in PRMT1 expression of murine placentas

Sato, A., Kim, J. D., Mizukami, H., Nakashima, M., Kako, K., Ishida, J., Itakura, A., Takeda, S. & Fukamizu, A., 2018/05, In: Placenta. 65, p. 47-54 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products

Murata, K., Lu, W., Hashimoto, M., Ono, N., Muratani, M., Nishikata, K., Kim, J. D., Ebihara, S., Ishida, J. & Fukamizu, A., 2018/10/26, In: iScience. 8, p. 200-213 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

30 被引用数 (Scopus)

The peroxisome proliferator-activated receptor α (PPARα) agonist pemafibrate protects against diet-induced obesity in mice

Araki, M., Nakagawa, Y., Oishi, A., Han, S. I., Wang, Y., Kumagai, K., Ohno, H., Mizunoe, Y., Iwasaki, H., Sekiya, M., Matsuzaka, T. & Shimano, H., 2018/07/23, In: International Journal of Molecular Sciences. 19, 7, 2148.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

65 被引用数 (Scopus)

2017

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Nishi-Tatsumi, M., Yahagi, N., Takeuchi, Y., Toya, N., Takarada, A., Murayama, Y., Aita, Y., Sawada, Y., Piao, X., Oya, Y., Shikama, A., Masuda, Y., Kubota, M., Izumida, Y., Matsuzaka, T., Nakagawa, Y., Sekiya, M., Iizuka, Y., Kawakami, Y. & Kadowaki, T. & 2 others, Yamada, N. & Shimano, H., 2017/04/01, In: FEBS Letters. 591, 7, p. 965-978 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry

Sawada, Y., Izumida, Y., Takeuchi, Y., Aita, Y., Wada, N., Li, E. X., Murayama, Y., Piao, X., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y., Iwasaki, H., Kobayashi, K., Yatoh, S. & Suzuki, H. & 5 others, Yagyu, H., Kawakami, Y., Kadowaki, T., Shimano, H. & Yahagi, N., 2017/11/04, In: Biochemical and Biophysical Research Communications. 493, 1, p. 40-45 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

和漢医薬学総合研究所研究開発部門複雑系解析分野

研究成果

検索結果