Complex Biosystem Research, Institute of Natural Medicine

2025

Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions

Nozaki, Y., Kobayashi, M., Fukuoh, T., Ishimatsu, M., Narita, T., Taki, K., Hirao, Y., Ayabe, S., Yokoyama, M., Otani, Y., Mizunoe, Y., Matsumoto, M., Ohno, N., Kaifu, T., Okazaki, S., Goitsuka, R., Nakagawa, Y., Shimano, H., Iwakura, Y. & Higami, Y., 2025/12, In: Scientific Reports. 15, 1, 12839.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease

Kashiwagi, M., Beck, G., Kanuka, M., Arai, Y., Tanaka, K., Tatsuzawa, C., Koga, Y., Saito, Y. C., Takagi, M., Oishi, Y., Sakaguchi, M., Baba, K., Ikuno, M., Yamakado, H., Takahashi, R., Yanagisawa, M., Murayama, S., Sakurai, T., Sakai, K. & Nakagawa, Y. & 3 others, Watanabe, M., Mochizuki, H. & Hayashi, Y., 2024/10/31, In: Cell. 187, 22, p. 6272-6289.e21

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation

Iyoda, T., Ohishi, A., Wang, Y., Yokoyama, M. S., Kazama, M., Okita, N., Inouye, S., Nakagawa, Y., Shimano, H. & Fukai, F., 2024/02, In: International Journal of Molecular Sciences. 25, 3, 1825.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Ishizawa, M., Fujihara, K., Yachida, J., Ikeda, I., Sato, T., Yamada, T., Kobayashi, A., Tanaka, S., Nakagawa, Y., Matsuzaka, T., Shimano, H., Tashiro, M., Kodama, S., Kato, K. & Sone, H., 2024/02, In: Journal of Bone Metabolism. 31, 1, p. 21-30 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Yanagisawa, A., Kim, J., Naito, A., Kobayashi, T., Misawa, T., Sakao, S., Jujo-Sanada, T., Kawasaki, T., Muroi, S. I., Sasaki, S. I., Suzuki, T., Hayakawa, Y., Nakagawa, Y., Kasuya, Y. & Tatsumi, K., 2024/12, In: Scientific Reports. 14, 1, 27069.

Research output: Contribution to journal › Article › peer-review

Open Access

Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis

Cao, Y., Araki, M., Nakagawa, Y., Deisen, L., Lundsgaard, A., Kanta, J. M., Holm, S., Johann, K., Brings Jacobsen, J. C., Jähnert, M., Schürmann, A., Kiens, B., Clemmensen, C., Shimano, H., Fritzen, A. M. & Kleinert, M., 2024/09, In: Molecular Metabolism. 87, 101991.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia

Furuta, Y., Osaki, Y., Nakagawa, Y., Han, S. I., Araki, M., Shikama, A., Ohuchi, N., Yamazaki, D., Matsuda, E., Nohara, S., Mizunoe, Y., Kainoh, K., Suehara, Y., Ohno, H., Takeuchi, Y., Miyamoto, T., Murayama, Y., Sugano, Y., Iwasaki, H. & Hirano, K. I. & 12 others, Koseki, M., Nakano, S., Tokiwa, H., Sekiya, M., Yahagi, N., Matsuzaka, T., Nakamagoe, K., Tomidokoro, Y., Mitsui, J., Tsuji, S., Suzuki, H. & Shimano, H., 2024, In: Journal of atherosclerosis and thrombosis. 31, 9, p. 1304-1318 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Hepatic ketone body regulation of renal gluconeogenesis

Hatano, R., Lee, E., Sato, H., Kiuchi, M., Hirahara, K., Nakagawa, Y., Shimano, H., Nakayama, T., Tanaka, T. & Miki, T., 2024/06, In: Molecular Metabolism. 84, 101934.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice

Fujisaka, S., Watanabe, Y., Toume, K., Morinaga, Y., Nawaz, A., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Igarashi, Y., Nakagawa, Y. & Tobe, K., 2024/07, In: Diabetology International. 15, 3, p. 495-506 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation

Kamei, K., Yahara, Y., Kim, J.-D., Tsuji, M., Iwasaki, M., Takemori, H., Seki, S., Makino, H., Futakawa, H., Hirokawa, T., Tung, N. T. C., Nakagawa, T. & Kawaguchi, Y., 2024/07/20, In: Journal of Bone and Mineral Research. 39, 9, p. 1340 1355 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages

Diercks, A. H., Podolskaia, I. S., Murray, T. A., Jahn, A. N., Mai, D., Liu, D., Amon, L. M., Nakagawa, Y., Shimano, H., Aderem, A. & Gold, E. S., 2024/08/13, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 33, e2406492121.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca²⁺ Allostasis Toward β-Cell Failure

Motomura, K., Matsuzaka, T., Shichino, S., Ogawa, T., Pan, H., Nakajima, T., Asano, Y., Okayama, T., Takeuchi, T., Ohno, H., Han, S. I., Miyamoto, T., Takeuchi, Y., Sekiya, M., Sone, H., Yahagi, N., Nakagawa, Y., Oda, T., Ueha, S. & Ikeo, K. & 3 others, Ogura, A., Matsushima, K. & Shimano, H., 2024/01, In: Diabetes. 73, 1, p. 75-92 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2023

ER proteostasis regulators cell-non-autonomously control sleep

Kawano, T., Kashiwagi, M., Kanuka, M., Chen, C. K., Yasugaki, S., Hatori, S., Miyazaki, S., Tanaka, K., Fujita, H., Nakajima, T., Yanagisawa, M., Nakagawa, Y. & Hayashi, Y., 2023/03/28, In: Cell Reports. 42, 3, 112267.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Watanabe, Y., Fujisaka, S., Morinaga, Y., Watanabe, S., Nawaz, A., Hatta, H., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Honda, K., Nakagawa, Y., Softic, S., Hirabayashi, K., Nakagawa, T., Nagai, Y. & Tobe, K., 2023/11, In: Molecular Metabolism. 77, 101797.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Macrophage SREBP1 regulates skeletal muscle regeneration

Oishi, Y., Koike, H., Kumagami, N., Nakagawa, Y., Araki, M., Taketomi, Y., Miki, Y., Matsuda, S., Matsuzaka, T., Ozawa, H., Shimano, H., Murakami, M. & Manabe, I., 2023, In: Frontiers in Immunology. 14, 1251784.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

Saito, K., Sekiya, M., Kainoh, K., Yoshino, R., Hayashi, A., Han, S. I., Araki, M., Ohno, H., Takeuchi, Y., Tsuyuzaki, T., Yamazaki, D., Wanpei, C., Hada, L., Watanabe, S., Paramita Adi Putri, P. I., Murayama, Y., Sugano, Y., Osaki, Y., Iwasaki, H. & Yahagi, N. & 4 others, Suzuki, H., Miyamoto, T., Matsuzaka, T. & Shimano, H., 2023/07, In: Journal of Biological Chemistry. 299, 7, 104890.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

Han, S. I., Nakakuki, M., Nakagawa, Y., Wang, Y., Araki, M., Yamamoto, Y., Tokiwa, H., Takeda, H., Mizunoe, Y., Motomura, K., Ohno, H., Kainoh, K., Murayama, Y., Aita, Y., Takeuchi, Y., Osaki, Y., Miyamoto, T., Sekiya, M., Matsuzaka, T. & Yahagi, N. & 5 others, Sone, H., Daitoku, H., Sato, R., Kawano, H. & Shimano, H., 2023/11/01, In: PNAS nexus. 2, 11, 2.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2022

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease

Araki, M., Nakagawa, Y., Saito, H., Yamada, Y., Han, S. I., Mizunoe, Y., Ohno, H., Miyamoto, T., Sekiya, M., Matsuzaka, T., Sone, H. & Shimano, H., 2022/12, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 323, 6, p. G627-G639

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at rest

Translated title of the contribution: High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at restYamazaki, R., Matsukiyo, S., Morita, T., Tanaka, S. J., Umeda, T., Aihara, K., Edamoto, M., Egashira, S., Hatsuyama, R., Higuchi, T., Hihara, T., Horie, Y., Hoshino, M., Ishii, A., Ishizaka, N., Itadani, Y., Izumi, T., Kambayashi, S., Kakuchi, S. & Katsuki, N. & 34 others, Kawamura, R., Kawamura, Y., Kisaka, S., Kojima, T., Konuma, A., Kumar, R., Minami, T., Miyata, I., Moritaka, T., Murakami, Y., Nagashima, K., Nakagawa, Y., Nishimoto, T., Nishioka, Y., Ohira, Y., Ohnishi, N., Ota, M., Ozaki, N., Sano, T., Sakai, K., Sei, S., Shiota, J., Shoji, Y., Sugiyama, K., Suzuki, D., Takagi, M., Toda, H., Tomita, S., Tomiya, S., Yoneda, H., Takezaki, T., Tomita, K., Kuramitsu, Y. & Sakawa, Y., 2022/02, In: Physical Review E. 105, p. 10883-

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

Okajima, Y., Matsuzaka, T., Miyazaki, S., Motomura, K., Ohno, H., Sharma, R., Shimura, T., Istiqamah, N., Han, S. I., Mizunoe, Y., Osaki, Y., Iwasaki, H., Yatoh, S., Suzuki, H., Sone, H., Miyamoto, T., Aita, Y., Takeuchi, Y., Sekiya, M. & Yahagi, N. & 3 others, Nakagawa, Y., Tomita, T. & Shimano, H., 2022/04/01, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1868, 4, 166339.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Multi-omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin

Kobayashi, T., Kim, J. D., Naito, A., Yanagisawa, A., Jujo-Sanada, T., Kasuya, Y., Nakagawa, Y., Sakao, S., Tatsumi, K. & Suzuki, T., 2022/05, In: International Journal of Molecular Medicine. 49, 5, 5124.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis

Kodama, S., Fujihara, K., Horikawa, C., Kitazawa, M., Iwanaga, M., Kato, K., Watanabe, K., Nakagawa, Y., Matsuzaka, T., Shimano, H. & Sone, H., 2022/05, In: Journal of Diabetes Investigation. 13, 5, p. 900-908 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

Yamada, Y., Saito, H., Araki, M., Tsuchimoto, Y., Muroi, S. I., Suzuki, K., Toume, K., Kim, J. D., Matsuzaka, T., Sone, H., Shimano, H. & Nakagawa, Y., 2022/10, In: Nutrients. 14, 19, 3920.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2021

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency

Cho, K., Ushiki, T., Ishiguro, H., Tamura, S., Araki, M., Suwabe, T., Katagiri, T., Watanabe, M., Fujimoto, Y., Ohashi, R., Ajioka, Y., Shimizu, I., Okuda, S., Masuko, M., Nakagawa, Y., Hirai, H., Alexander, W. S., Shimano, H. & Sone, H., 2021/10/22, In: iScience. 24, 10, 103117.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Dinh, T. T. H., Iseki, H., Mizuno, S., Iijima-Mizuno, S., Tanimoto, Y., Daitoku, Y., Kato, K., Hamada, Y., Hasan, A. S. H., Suzuki, H., Murata, K., Muratani, M., Ema, M., Kim, J. D., Ishida, J., Fukamizu, A., Kato, M., Takahashi, S., Yagami, K. I. & Wilson, V. & 2 others, Arkell, R. M. & Sugiyama, F., 2021/05, In: eLife. 10, e50346.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

Nakagawa, Y., Wang, Y., Han, S. I., Okuda, K., Oishi, A., Yagishita, Y., Kumagai, K., Ohno, H., Osaki, Y., Mizunoe, Y., Araki, M., Murayama, Y., Iwasaki, H., Konishi, M., Itoh, N., Matsuzaka, T., Sone, H., Yamada, N. & Shimano, H., 2021/01, In: CMGH. 11, 4, p. 949-971 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development

Hashimoto, M., Kumabe, A., Kim, J. D., Murata, K., Sekizar, S., Williams, A., Lu, W., Ishida, J., Nakagawa, T., Endo, M., Minami, Y. & Fukamizu, A., 2021/03, In: Journal of Neurochemistry. 156, 6, p. 834-847 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle

Mizunoe, Y., Kobayashi, M., Saito, H., Goto, A., Migitaka, R., Miura, K., Okita, N., Sudo, Y., Tagawa, R., Yoshida, M., Umemori, A., Nakagawa, Y., Shimano, H. & Higami, Y., 2021/10/15, In: Experimental Gerontology. 154, 111519.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling

Nakagawa, Y., Kumagai, K., Han, S. I., Mizunoe, Y., Araki, M., Mizuno, S., Ohno, H., Matsuo, K., Yamada, Y., Kim, J. D., Miyamoto, T., Sekiya, M., Konishi, M., Itoh, N., Matsuzaka, T., Takahashi, S., Sone, H. & Shimano, H., 2021/06, In: FASEB Journal. 35, 6, e21663.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment

Satou-Kobayashi, Y., Kim, J. D., Fukamizu, A. & Asashima, M., 2021/12, In: Scientific Reports. 11, 1, 14537.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2020

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Satoh, A., Han, S. I., Araki, M., Nakagawa, Y., Ohno, H., Mizunoe, Y., Kumagai, K., Murayama, Y., Osaki, Y., Iwasaki, H., Sekiya, M., Konishi, M., Itoh, N., Matsuzaka, T., Sone, H. & Shimano, H., 2020/03/27, In: iScience. 23, 3, 100930.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming

Noguchi, K., Ishida, J., Kim, J. D., Muromachi, N., Kako, K., Mizukami, H., Lu, W., Ishimaru, T., Kawasaki, S., Kaneko, S., Usui, J., Ohtsu, H., Yamagata, K. & Fukamizu, A., 2020/02/11, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3150-3156 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Srebp-1c/Fgf21/Pgc-1α axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose tissue

Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H. & Higami, Y., 2020/07, In: Nutrients. 12, 7, p. 1-15 15 p., 2054.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1

Ma, Y., Sekiya, M., Kainoh, K., Matsuda, T., Iwasaki, H., Osaki, Y., Sugano, Y., Suzuki, H., Takeuchi, Y., Miyamoto, T., Yahagi, N., Nakagawa, Y., Matsuzaka, T. & Shimano, H., 2020/03/05, In: Biochemical and Biophysical Research Communications. 523, 2, p. 354-360 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

Suzuki, K., Kim, J. D., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K. & Kasuya, Y., 2020/08, In: Molecular Medicine Reports. 22, 2, p. 1518-1526 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Transcriptomic evaluation of pulmonary fibrosis-related genes: Utilization of transgenic mice with modifying p38 signal in the lungs

Matsuda, S., Kim, J. D., Sugiyama, F., Matsuo, Y., Ishida, J., Murata, K., Nakamura, K., Namiki, K., Sudo, T., Kuwaki, T., Hatano, M., Tatsumi, K., Fukamizu, A. & Kasuya, Y., 2020/09/02, In: International Journal of Molecular Sciences. 21, 18, p. 1-17 17 p., 6746.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism

Hoshino, S., Kobayashi, M., Tagawa, R., Konno, R., Abe, T., Furuya, K., Miura, K., Wakasawa, H., Okita, N., Sudo, Y., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Kawabe, H. & Higami, Y., 2020/03/01, In: FEBS Open Bio. 10, 3, p. 306-315 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2019

Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction

Nagano, K., Kwon, C., Ishida, J., Hashimoto, T., Kim, J. D., Kishikawa, N., Murao, M., Kimura, K., Kasuya, Y., Kimura, S., Chen, Y. C., Tsuchimochi, H., Shirai, M., Pearson, J. T. & Fukamizu, A., 2019/11/01, In: Journal of Biochemistry. 166, 5, p. 383-392 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Dietary protein restriction increases hepatic leptin receptor mRNA and plasma soluble leptin receptor in male rodents

Yamada, R., Odamaki, S., Araki, M., Watanabe, T., Matsuo, K., Uchida, K., Kato, T., Ozaki-Masuzawa, Y. & Takenaka, A., 2019/07/01, In: PLoS ONE. 14, 7, e0219603.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

Qin, R., Murakoshi, N., Xu, D. Z., Tajiri, K., Feng, D., Stujanna, E. N., Yonebayashi, S., Nakagawa, Y., Shimano, H., Nogami, A., Koike, A., Aonuma, K. & Ieda, M., 2019/02, In: Physiological Reports. 7, 4, e13972.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

Murayama, Y., Yahagi, N., Takeuchi, Y., Aita, Y., Mehrazad Saber, Z., Wada, N., Li, E. X., Piao, X., Sawada, Y., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Izumida, Y., Miyamoto, T., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y. & Iwasaki, H. & 6 others, Kobayashi, K., Yatoh, S., Suzuki, H., Yagyu, H., Kawakami, Y. & Shimano, H., 2019/02, In: FEBS Letters. 593, 4, p. 423-432 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts

Mizukami, H., Kim, J. D., Tabara, S., Lu, W., Kwon, C., Nakashima, M. & Fukamizu, A., 2019/04/01, In: Journal of Biochemistry. 165, 4, p. 335-342 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation

Lu, W., Kim, J. D., Tabara, S., Kwon, C., Mizukami, H., Kimura, K. & Fukamizu, A., 2019/07/05, In: Biochemical and Biophysical Research Communications. 514, 4, p. 1185-1191 7 p.

Research output: Contribution to journal › Article › peer-review

2018

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes

Piao, X., Yahagi, N., Takeuchi, Y., Aita, Y., Murayama, Y., Sawada, Y., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Izumida, Y., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y., Iwasaki, H., Kobayashi, K., Yatoh, S., Suzuki, H. & Yagyu, H. & 2 others, Kawakami, Y. & Shimano, H., 2018/02, In: FEBS Letters. 592, 3, p. 422-433 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

Yuan, X., Tsujimoto, K., Hashimoto, K., Kawahori, K., Hanzawa, N., Hamaguchi, M., Seki, T., Nawa, M., Ehara, T., Kitamura, Y., Hatada, I., Konishi, M., Itoh, N., Nakagawa, Y., Shimano, H., Takai-Igarashi, T., Kamei, Y. & Ogawa, Y., 2018/12/01, In: Nature Communications. 9, 1, 636.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Gestational changes in PRMT1 expression of murine placentas

Sato, A., Kim, J. D., Mizukami, H., Nakashima, M., Kako, K., Ishida, J., Itakura, A., Takeda, S. & Fukamizu, A., 2018/05, In: Placenta. 65, p. 47-54 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products

Murata, K., Lu, W., Hashimoto, M., Ono, N., Muratani, M., Nishikata, K., Kim, J. D., Ebihara, S., Ishida, J. & Fukamizu, A., 2018/10/26, In: iScience. 8, p. 200-213 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

The peroxisome proliferator-activated receptor α (PPARα) agonist pemafibrate protects against diet-induced obesity in mice

Araki, M., Nakagawa, Y., Oishi, A., Han, S. I., Wang, Y., Kumagai, K., Ohno, H., Mizunoe, Y., Iwasaki, H., Sekiya, M., Matsuzaka, T. & Shimano, H., 2018/07/23, In: International Journal of Molecular Sciences. 19, 7, 2148.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2017

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Nishi-Tatsumi, M., Yahagi, N., Takeuchi, Y., Toya, N., Takarada, A., Murayama, Y., Aita, Y., Sawada, Y., Piao, X., Oya, Y., Shikama, A., Masuda, Y., Kubota, M., Izumida, Y., Matsuzaka, T., Nakagawa, Y., Sekiya, M., Iizuka, Y., Kawakami, Y. & Kadowaki, T. & 2 others, Yamada, N. & Shimano, H., 2017/04/01, In: FEBS Letters. 591, 7, p. 965-978 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry

Sawada, Y., Izumida, Y., Takeuchi, Y., Aita, Y., Wada, N., Li, E. X., Murayama, Y., Piao, X., Shikama, A., Masuda, Y., Nishi-Tatsumi, M., Kubota, M., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Sugano, Y., Iwasaki, H., Kobayashi, K., Yatoh, S. & Suzuki, H. & 5 others, Yagyu, H., Kawakami, Y., Kadowaki, T., Shimano, H. & Yahagi, N., 2017/11/04, In: Biochemical and Biophysical Research Communications. 493, 1, p. 40-45 6 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Complex Biosystem Research, Institute of Natural Medicine

Research output

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