@article{040da51a4abb49c0bc9150f39e47f833,
title = "Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex",
abstract = "Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor (GR) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the suppressive effect of the GR on the expression of Rev-erbα (Nr1d1), an important component of the clock regulatory circuits. Here we show that the GR suppresses Rev-erbα expression via the formation of a complex with CLOCK and BMAL1, which binds to the E-boxes in the Nr1d1 promoter. In this GR-CLOCK-BMAL1 complex, the GR does not directly bind to DNA, which is referred to as tethering. These findings provide new insights into the role of the GR in the control of circadian rhythm.",
keywords = "circadian rhythm, clock, glucocorticoid receptor, glucocorticoids, tethering",
author = "Yuki Murayama and Naoya Yahagi and Yoshinori Takeuchi and Yuichi Aita and {Mehrazad Saber}, Zahra and Nobuhiro Wada and Li, {En Xu} and Xianying Piao and Yoshikazu Sawada and Akito Shikama and Yukari Masuda and Makiko Nishi-Tatsumi and Midori Kubota and Yoshihiko Izumida and Takafumi Miyamoto and Motohiro Sekiya and Takashi Matsuzaka and Yoshimi Nakagawa and Yoko Sugano and Hitoshi Iwasaki and Kazuto Kobayashi and Shigeru Yatoh and Hiroaki Suzuki and Hiroaki Yagyu and Yasushi Kawakami and Hitoshi Shimano",
note = "Publisher Copyright: {\textcopyright} 2019 Federation of European Biochemical Societies",
year = "2019",
month = feb,
doi = "10.1002/1873-3468.13328",
language = "英語",
volume = "593",
pages = "423--432",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "4",
}