Engineered group i ribozymes as RNA-based modular tools to control gene expression

Yoshiya Ikawa; Shigeyoshi Matsumura

doi:10.1007/978-981-10-8372-3_13

Engineered group i ribozymes as RNA-based modular tools to control gene expression

Yoshiya Ikawa^*, Shigeyoshi Matsumura

^*この論文の責任著者

化学科

研究成果: 書籍の章/レポート/会議録 › 章 › 査読

3 被引用数 (Scopus)

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Group I ribozymes (RNA enzymes) constitute a class of structural RNAs that promote cleavage and ligation of phosphodiester bonds to conduct RNA splicing. As naturally occurring group I ribozymes are constitutively active in most cases, modular engineering is required to apply them to control gene expression. We first introduce exceptional examples of modified splicing reactions of group I ribozymes. We then summarize strategies to engineer group I ribozymes to develop genetic modular tools and also their application to gene expression control.

本文言語	英語
ホスト出版物のタイトル	Applied RNA Bioscience
出版社	Springer Singapore
ページ	203-220
ページ数	18
ISBN（電子版）	9789811083723
ISBN（印刷版）	9789811083716
DOI	https://doi.org/10.1007/978-981-10-8372-3_13
出版ステータス	出版済み - 2018/04/10

ASJC Scopus 主題領域

生化学、遺伝学、分子生物学一般
医学一般

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10.1007/978-981-10-8372-3_13

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abstract = "Group I ribozymes (RNA enzymes) constitute a class of structural RNAs that promote cleavage and ligation of phosphodiester bonds to conduct RNA splicing. As naturally occurring group I ribozymes are constitutively active in most cases, modular engineering is required to apply them to control gene expression. We first introduce exceptional examples of modified splicing reactions of group I ribozymes. We then summarize strategies to engineer group I ribozymes to develop genetic modular tools and also their application to gene expression control.",

keywords = "Alternative splicing, Aptamer, Group I intron, RNA structure, Ribozyme, Self-splicing, Trans-splicing",

author = "Yoshiya Ikawa and Shigeyoshi Matsumura",

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year = "2018",

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doi = "10.1007/978-981-10-8372-3_13",

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AU - Ikawa, Yoshiya

AU - Matsumura, Shigeyoshi

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2018.

PY - 2018/4/10

Y1 - 2018/4/10

N2 - Group I ribozymes (RNA enzymes) constitute a class of structural RNAs that promote cleavage and ligation of phosphodiester bonds to conduct RNA splicing. As naturally occurring group I ribozymes are constitutively active in most cases, modular engineering is required to apply them to control gene expression. We first introduce exceptional examples of modified splicing reactions of group I ribozymes. We then summarize strategies to engineer group I ribozymes to develop genetic modular tools and also their application to gene expression control.

AB - Group I ribozymes (RNA enzymes) constitute a class of structural RNAs that promote cleavage and ligation of phosphodiester bonds to conduct RNA splicing. As naturally occurring group I ribozymes are constitutively active in most cases, modular engineering is required to apply them to control gene expression. We first introduce exceptional examples of modified splicing reactions of group I ribozymes. We then summarize strategies to engineer group I ribozymes to develop genetic modular tools and also their application to gene expression control.

KW - Alternative splicing

KW - Aptamer

KW - Group I intron

KW - RNA structure

KW - Ribozyme

KW - Self-splicing

KW - Trans-splicing

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Engineered group i ribozymes as RNA-based modular tools to control gene expression

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ASJC Scopus 主題領域

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