年別の研究成果
年別の研究成果
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2025
Digoxin promotes anoikis of circulating cancer cells by targeting Na+/K+-ATPase α3-isoform
Numata, Y., Fujii, T., Toda, C., Okumura, T., Manabe, T., Takeda, N., Shimizu, T., Tabuchi, Y., Fujii, T. & Sakai, H., 2025/12, In: Cell Death and Disease. 16, 1, 373.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Ion Channel Function of Human TMEM16F Is Associated with Phospholipid Transport through Its Subunit Cavity
Kageyama, T., Shimizu, T., Shirai, K., Nabeshima, S., Ozawa, S., Fujii, T., Yonekawa, Y. & Sakai, H., 2025/05, In: Biological and Pharmaceutical Bulletin. 48, 5, p. 595-605 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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2023
Activation of mouse Otop3 proton channels by Zn2+
Fujii, T., Shimizu, T., Kaji, Y., Katoh, M. & Sakai, H., 2023/05/28, In: Biochemical and Biophysical Research Communications. 658, p. 55-61 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Novel pathophysiological functions of Na+,K+-ATPases and Cl− channels in cancer cells
Fujii, T., Shimizu, T. & Sakai, H., 2023, In: Folia Pharmacologica Japonica. 158, 6, p. 465-468 4 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
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Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase
Fujii, T., Nagamori, S., Wiriyasermkul, P., Zheng, S., Yago, A., Shimizu, T., Tabuchi, Y., Okumura, T., Fujii, T., Takeshima, H. & Sakai, H., 2023/12, In: Nature Communications. 14, 1, 2174.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access23 被引用数 (Scopus) -
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine
Shimizu, T., Fujii, T., Hanita, K., Shinozaki, R., Takamura, Y., Suzuki, Y., Kageyama, T., Kato, M., Nishijo, H., Tominaga, M. & Sakai, H., 2023/12, In: Scientific Reports. 13, 1, 4271.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
2022
Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+,K+-ATPase α3-isoform in human cancer cells
Fujii, T., Katoh, M., Ootsubo, M., Nguyen, O. T. T., Iguchi, M., Shimizu, T., Tabuchi, Y., Shimizu, Y., Takeshima, H. & Sakai, H., 2022/07, In: Journal of Cellular Physiology. 237, 7, p. 2980-2991 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
13 被引用数 (Scopus) -
Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin
Shimizu, T., Yanase, N., Fujii, T., Sakakibara, H. & Sakai, H., 2022/02/01, In: Biochimica et Biophysica Acta - Biomembranes. 1864, 1, 183782.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2021
Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008
Fujii, T., Sugimoto, K., Noda, T., Shimizu, T., Matsuya, Y. & Sakai, H., 2021/08/27, In: Biochemical and Biophysical Research Communications. 567, p. 177-182 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase
Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., Fujii, T., Takeshima, H. & Sakai, H., 2021/05/21, In: iScience. 24, 5, 102412.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access13 被引用数 (Scopus) -
Total synthesis of decahydroquinoline poison frog alkaloids ent-cis-195a and cis-211a
Okada, T., Wu, N., Takashima, K., Ishimura, J., Morita, H., Ito, T., Kodama, T., Yamasaki, Y., Akanuma, S. I., Kubo, Y., Hosoya, K. I., Tsuneki, H., Wada, T., Sasaoka, T., Shimizu, T., Sakai, H., Dwoskin, L. P., Hussaini, S. R., Saporito, R. A. & Toyooka, N., 2021/12/01, In: Molecules. 26, 24, 7529.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
2020
Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume-sensitive Cl− channels in human epidermoid carcinoma cells
Shimizu, T., Fujii, T., Ohtake, H., Tomii, T., Takahashi, R., Kawashima, K. & Sakai, H., 2020/12/01, In: Journal of Cellular Physiology. 235, 12, p. 9589-9600 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells
Kawai, S., Fujii, T., Shimizu, T., Sukegawa, K., Hashimoto, I., Okumura, T., Nagata, T., Sakai, H. & Fujii, T., 2020/02/17, In: Journal of Physiological Sciences. 70, 1, 15.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
The Relationship Between Actin Cytoskeleton and Membrane Transporters in Cisplatin Resistance of Cancer Cells
Shimizu, T., Fujii, T. & Sakai, H., 2020/10/27, In: Frontiers in Cell and Developmental Biology. 8, 597835.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access18 被引用数 (Scopus) -
地方大学医療系キャンパスでのオンライン授業導入報告
Mihara, H., Kishi, H., Adachi, Y., Shimizu, T., Sakai, H., Oku, M. & Fujii, A., 2020, In: 医学教育. 51, 3, p. 255-257 3 p.研究成果: ジャーナルへの寄稿 › 学術論文
Open Access -
2019
Cancer cell-specific functional relation between Na+,K+-ATPase and volume-regulated anion channel
Fujii, T., Shimizu, T., Takeshima, H. & Sakai, H., 2019, In: Folia Pharmacologica Japonica. 154, 3, p. 103-107 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Cell volume-activated and volume-correlated anion channels in mammalian cells: Their biophysical, molecular, and pharmacological properties
Okada, Y., Okada, T., Sato-Numata, K., Islam, M. R., Ando-Akatsuka, Y., Numata, T., Kubo, M., Shimizu, T., Kurbannazarova, R. S., Marunaka, Y. & Sabirov, R. Z., 2019/01, In: Pharmacological Reviews. 71, 1, p. 49-88 40 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access71 被引用数 (Scopus) -
Negative regulation of gastric proton pump by desialylation suggested by fluorescent imaging with the sialic acid-specific nanoprobe
Fujii, T., Shimizu, T., Kushiro, K., Takeshima, H., Takai, M. & Sakai, H., 2019, In: Folia Pharmacologica Japonica. 153, 6, p. 261-266 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Non-morphogenic effect of Sonic Hedgehog on gastric H+,K+-ATPase activity
Fujii, T., Phutthatiraphap, S., Shimizu, T., Takeshima, H. & Sakai, H., 2019/10/20, In: Biochemical and Biophysical Research Communications. 518, 3, p. 605-609 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
2018
Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells
Fujii, T., Shimizu, T., Yamamoto, S., Funayama, K., Fujita, K., Tabuchi, Y., Ikari, A., Takeshima, H. & Sakai, H., 2018/11, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 11, p. 3792-3804 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access41 被引用数 (Scopus) -
2017
The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation
Shimizu, T., Higuchi, T., Toba, T., Ohno, C., Fujii, T., Nilius, B. & Sakai, H., 2017/09, In: FEBS Open Bio. 7, 9, p. 1392-1401 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
2016
Positive regulation of the enzymatic activity of gastric H+,K+-ATPase by sialylation of its β-subunit
Fujii, T., Watanabe, M., Shimizu, T., Takeshima, H., Kushiro, K., Takai, M. & Sakai, H., 2016/06/01, In: Biochimica et Biophysica Acta - Biomembranes. 1858, 6, p. 1228-1235 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2015
Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel
Fujii, T., Takahashi, Y., Takeshima, H., Saitoh, C., Shimizu, T., Takeguchi, N. & Sakai, H., 2015/08/13, In: European Journal of Pharmacology. 765, p. 34-41 8 p., EJP41856.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
26 被引用数 (Scopus) -
Volume-sensitive outwardly rectifying Cl− channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells
Shimizu, T., Ohtake, H., Fujii, T., Tabuchi, Y. & Sakai, H., 2015/03/19, In: Journal of Physiological Sciences. 65, 2, p. 151-157 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2014
Functional coupling of chloride-proton exchanger ClC-5 to gastric H+,K+-ATPase
Takahashi, Y., Fujii, T., Fujita, K., Shimizu, T., Higuchi, T., Tabuchi, Y., Sakamoto, H., Naito, I., Manabe, K., Uchida, S., Sasaki, S., Ikari, A., Tsukada, K. & Sakai, H., 2014/01/15, In: Biology Open. 3, 1, p. 12-21 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access14 被引用数 (Scopus) -
Gating modulation by heat of the polycystin transient receptor potential channel PKD2L1 (TRPP3)
Higuchi, T., Shimizu, T., Fujii, T., Nilius, B. & Sakai, H., 2014/10, In: Pflugers Archiv European Journal of Physiology. 466, 10, p. 1933-1940 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
13 被引用数 (Scopus) -
Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation
Shimizu, T., Fujii, T., Takahashi, Y., Takahashi, Y., Suzuki, T., Ukai, M., Tauchi, K., Horikawa, N., Tsukada, K. & Sakai, H., 2014/03, In: Pflugers Archiv European Journal of Physiology. 466, 3, p. 541-548 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
18 被引用数 (Scopus) -
2013
Modulation of H+,K+-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells
Fujii, T., Awaka, S. Y., Takahashi, Y., Fujita, K., Tsuji, H., Shimizu, T., Gomi, T., Tsukada, K. & Sakai, H., 2013/12/11, In: FEBS Letters. 587, 24, p. 3898-3905 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel
Shimizu, T., Iehara, T., Sato, K., Fujii, T., Sakai, H. & Okada, Y., 2013/04/15, In: American Journal of Physiology - Cell Physiology. 304, 8, p. C748-C759研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
111 被引用数 (Scopus) -
2012
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells
Fujii, T., Minagawa, T., Shimizu, T., Takeguchi, N. & Sakai, H., 2012/01, In: Journal of Physiological Sciences. 62, 1, p. 53-58 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells
Ando-Akatsuka, Y., Shimizu, T., Numata, T. & Okada, Y., 2012/10, In: Journal of Cellular Physiology. 227, 10, p. 3498-3510 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
24 被引用数 (Scopus) -
Role of cholesterol in functional association between K +-Cl - cotransporter-3a and Na +,K +-ATPase
Fujita, K., Fujii, T., Shimizu, T., Takeguchi, N. & Sakai, H., 2012/07/20, In: Biochemical and Biophysical Research Communications. 424, 1, p. 136-140 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
The apoptotic volume decrease is an upstream event of MAP kinase activation during staurosporine-induced apoptosis in HeLa cells
Hasegawa, Y., Shimizu, T., Takahashi, N. & Okada, Y., 2012/07, In: International Journal of Molecular Sciences. 13, 7, p. 9363-9379 17 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access26 被引用数 (Scopus) -
2011
Bimodal effect of alkalization on the polycystin transient receptor potential channel, PKD2L1
Shimizu, T., Higuchi, T., Fujii, T., Nilius, B. & Sakai, H., 2011/05, In: Pflugers Archiv European Journal of Physiology. 461, 5, p. 507-513 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
22 被引用数 (Scopus) -
2010
A new player in apoptosis triggered with anti-cancer drugs: The volume-sensitive outwardly-rectifying Cl- Channel
Shimizu, T., 2010/06/01, In: Cancer Biology and Therapy. 9, 11, p. 892-894 3 p.研究成果: ジャーナルへの寄稿 › コメント/討論
Open Access2 被引用数 (Scopus) -
Increase in ouabain-sensitive K+-ATPase activity in hepatocellular carcinoma by overexpression of Na+,K+-ATPase α3-isoform
Shibuya, K., Fukuoka, J., Fujii, T., Shimoda, E., Shimizu, T., Sakai, H. & Tsukada, K., 2010/07, In: European Journal of Pharmacology. 638, 1-3, p. 42-46 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
22 被引用数 (Scopus) -
The NH2-terminus of K+-Cl- cotransporter 3a is essential for up-regulation of Na+,K+-ATPase activity
Fujii, T., Fujita, K., Shimizu, T., Takeguchi, N. & Sakai, H., 2010/09, In: Biochemical and Biophysical Research Communications. 399, 4, p. 683-687 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
2009
Bradykinin-induced astrocyte-neuron signalling: Glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
Liu, H. T., Akita, T., Shimizu, T., Sabirov, R. Z. & Okada, Y., 2009, In: Journal of Physiology. 587, 10, p. 2197-2209 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access90 被引用数 (Scopus) -
Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume
Shimizu, T., Janssens, A., Voets, T. & Nilius, B., 2009/02, In: Pflugers Archiv European Journal of Physiology. 457, 4, p. 795-807 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access68 被引用数 (Scopus) -
2007
Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells
Lee, E. L., Shimizu, T., Ise, T., Numata, T., Kohno, K. & Okada, Y., 2007/05, In: Journal of Cellular Physiology. 211, 2, p. 513-521 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
75 被引用数 (Scopus) -
2006
Normotonic cell shrinkage induces apoptosis under extracellular low Cl - conditions in human lymphoid and epithelial cells
Maeno, E., Shimizu, T. & Okada, Y., 2006/05, In: Acta Physiologica. 187, 1-2, p. 217-222 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
41 被引用数 (Scopus) -
2005
Single-channel properties of volume-sensitive Cl- channel in ClC-3-deficient cardiomyocytes
Wang, J., Xu, H., Morishima, S., Tanabe, S., Jishage, K., Uchida, S., Sasaki, S., Okada, Y. & Shimizu, T., 2005, In: Japanese Journal of Physiology. 55, 6, p. 379-383 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access26 被引用数 (Scopus) -
2004
A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl- channel
Shimizu, T., Numata, T. & Okada, Y., 2004/04/27, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 17, p. 6770-6773 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access225 被引用数 (Scopus) -
ClC-3-independent, PKC-dependent activity of volume-sensitive Cl - channel in mouse ventricular cardiomyocytes
Gong, W., Xu, H., Shimizu, T., Morishima, S., Tanabe, S., Tachibe, T., Uchida, S., Sasaki, S. & Okada, Y., 2004, In: Cellular Physiology and Biochemistry. 14, 4-6, p. 213-224 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
69 被引用数 (Scopus) -
Expression of novel isoforms of the ClC-1 chloride channel, in astrocytic glial cells in vitro
Zhang, X. D., Morishima, S., Ando-Akatsuka, Y., Takahashi, N., Nabekura, T., Inoue, H., Shimizu, T. & Okada, Y., 2004/07, In: GLIA. 47, 1, p. 46-57 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access14 被引用数 (Scopus) -
2003
Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation
Wehner, F., Shimizu, T., Sabirov, R. & Okada, Y., 2003/09/11, In: FEBS Letters. 551, 1-3, p. 20-24 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
37 被引用数 (Scopus) -
2002
Molecular and pharmacological properties of inwardly rectifying K+ channels of human lung cancer cells
Sakai, H., Shimizu, T., Hori, K., Ikari, A., Asano, S. & Takeguchi, N., 2002/01/25, In: European Journal of Pharmacology. 435, 2-3, p. 125-133 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
23 被引用数 (Scopus) -
2001
Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)
Okada, Y., Maeno, E., Shimizu, T., Dezaki, K., Wang, J. & Morishima, S., 2001/04/01, In: Journal of Physiology. 532, 1, p. 3-16 14 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access478 被引用数 (Scopus) -
2000
Ca2+-sensing receptor-mediated regulation of volume-sensitive Cl- channels in human epithelial cells
Shimizu, T., Morishima, S. & Okada, Y., 2000/11/01, In: Journal of Physiology. 528, 3, p. 457-472 16 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access25 被引用数 (Scopus) -
1998
Cyclic GMP-dependent cytoprotection against ethanol-induced damage in rabbit isolated gastric parietal cells
Sakai, H., Ikari, A., Shimizu, T., Sato, T. & Takeguchi, N., 1998/11/13, In: European Journal of Pharmacology. 361, 1, p. 109-117 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
8 被引用数 (Scopus)