TY - JOUR
T1 - Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature
AU - Honoki, Hisae
AU - Yagi, Kunimasa
AU - Tsuda, Sayaka
AU - Wada, Tsutomu
AU - Enkaku, Asako
AU - Nakagawa-Yokoyama, Maki
AU - Kamigishi, Miki
AU - Shikata, Masataka
AU - Takikawa-Nishiday, Akiko
AU - Fujisaka, Shiho
AU - Chujo, Daisuke
AU - Sasaoka, Toshiyasu
AU - Nakashima, Akitoshi
AU - Saito, Shigeru
AU - Tobe, Kazuyuki
N1 - Publisher Copyright:
© 2021, The Japan Diabetes Society.
PY - 2021/7
Y1 - 2021/7
N2 - Sensor-augmented insulin pump therapy with a predictive low glucose suspend (SAP-PLGS) feature is a remarkably progressed modality for the glycemic management of patients with type 1 diabetes. This technology avoids nocturnal hypoglycemia and severe hypoglycemia. A Brazilian woman developed type 1 diabetes at age 11 and was treated with multiple daily insulin injections. At age 20, she was admitted to our internal medicine department for her first pregnancy. Her HbA1c was 7.9% in the 6 weeks of gestation. Although the combination of continuous subcutaneous insulin infusion and a sensor-augmented pump was introduced, she had a miscarriage in the next week. After 6 months, she became pregnant again. Despite an HbA1c of 7.2%, she had another miscarriage. Thereafter, she returned to multiple daily insulin injections and began using intermittently scanned continuous glycemic monitoring. At age 22, she had her third pregnancy. Her HbA1c was 7.3%. SAP-PLGS was then introduced, which reduced her frequent hypoglycemic events and blood glucose fluctuations. She gave birth to a 4137 g boy at 39 weeks without significant complications. Successful delivery can be obtained in women with type 1 diabetes following repeated miscarriages after introducing SAP-PLGS. We hypothesize that the modality might contributed to our patient’s miscarriage avoidance by reducing her glycemic fluctuations.
AB - Sensor-augmented insulin pump therapy with a predictive low glucose suspend (SAP-PLGS) feature is a remarkably progressed modality for the glycemic management of patients with type 1 diabetes. This technology avoids nocturnal hypoglycemia and severe hypoglycemia. A Brazilian woman developed type 1 diabetes at age 11 and was treated with multiple daily insulin injections. At age 20, she was admitted to our internal medicine department for her first pregnancy. Her HbA1c was 7.9% in the 6 weeks of gestation. Although the combination of continuous subcutaneous insulin infusion and a sensor-augmented pump was introduced, she had a miscarriage in the next week. After 6 months, she became pregnant again. Despite an HbA1c of 7.2%, she had another miscarriage. Thereafter, she returned to multiple daily insulin injections and began using intermittently scanned continuous glycemic monitoring. At age 22, she had her third pregnancy. Her HbA1c was 7.3%. SAP-PLGS was then introduced, which reduced her frequent hypoglycemic events and blood glucose fluctuations. She gave birth to a 4137 g boy at 39 weeks without significant complications. Successful delivery can be obtained in women with type 1 diabetes following repeated miscarriages after introducing SAP-PLGS. We hypothesize that the modality might contributed to our patient’s miscarriage avoidance by reducing her glycemic fluctuations.
KW - Glycemic fluctuations
KW - PLGS
KW - Pregnancy
KW - SAP
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85102074801&partnerID=8YFLogxK
U2 - 10.1007/s13340-020-00489-9
DO - 10.1007/s13340-020-00489-9
M3 - 学術論文
C2 - 34150440
AN - SCOPUS:85102074801
SN - 2190-1678
VL - 12
SP - 324
EP - 329
JO - Diabetology International
JF - Diabetology International
IS - 3
ER -