術前にプロトロンビン複合体製剤の予防投与を行ったProthrombin Himiの1例

Translated title of the contribution: Successful preoperative replacement of prothrombin with prothrombin complex concentrate for Prothrombin Himi

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Abstract

Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood coagulation evaluation revealed a prolonged prothrombin time (39%) and activated partial thromboplastin (64.4 sec), with an isolated severe decrease in the prothrombin activity (8.6%). Preoperative replacement of prothrombin with prothrombin complex concentrate, PPSB-HT "Nichiyaku," successfully prevented abnormal postoperative bleeding after laparoscopic hysterectomy for cervical cancer. This is the second reported case of Prothrombin Himi.

Translated title of the contributionSuccessful preoperative replacement of prothrombin with prothrombin complex concentrate for Prothrombin Himi
Original languageJapanese
Pages (from-to)1412-1414
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume62
Issue number9
DOIs
StatePublished - 2021
Externally publishedYes

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