抄録
Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood coagulation evaluation revealed a prolonged prothrombin time (39%) and activated partial thromboplastin (64.4 sec), with an isolated severe decrease in the prothrombin activity (8.6%). Preoperative replacement of prothrombin with prothrombin complex concentrate, PPSB-HT "Nichiyaku," successfully prevented abnormal postoperative bleeding after laparoscopic hysterectomy for cervical cancer. This is the second reported case of Prothrombin Himi.
| 寄稿の翻訳タイトル | Successful preoperative replacement of prothrombin with prothrombin complex concentrate for Prothrombin Himi |
|---|---|
| 本文言語 | 日本 |
| ページ（範囲） | 1412-1414 |
| ページ数 | 3 |
| ジャーナル | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| 巻 | 62 |
| 号 | 9 |
| DOI | |
| 出版ステータス | 出版済み - 2021 |
| 外部発表 | はい |
キーワード
- Blood Coagulation Factors
- Humans
- Prothrombin
