The similarity between pregnant immunity and tumor immunity

  • SAITHO, Shigeru (Principal Investigator)
  • 中村隆文 (Co-Investigator(Kenkyū-buntansha))
  • 若杉聡美 (Co-Investigator(Kenkyū-buntansha))
  • 酒井正利 (Co-Investigator(Kenkyū-buntansha))
  • 日高, 隆雄 (Co-Investigator(Kenkyū-buntansha))
  • 佐々木, 泰和 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

We found immunoregulatory NK cells using leukemic mice model The surface markers of regulatory NK cells are CD94^-, acialo GMI^+, CD25^(++), CD122^(++), Thy 1, 2^(++), c - kit^+, CD3^-, DX5^+. These NK cells produced TGF - β and inhibited MEIC class II antigens on DC, and inhibited the induction of cytotoxic T cell. Interestingly, these NK cells were increased in the pregnancy uterus in mice. These NK cells were also detected in pregnancy NOD / SCID mice. We discovered these regulatory NK cells from the tumor bearing mice and pregnant mice. We confirm the similarity between tumor immunity and pregnant immunity.
StatusFinished
Effective start/end date2005/01/01 → 2007/12/31

Funding

  • Japan Society for the Promotion of Science: ¥16,270,000.00

Keywords

  • 妊娠免疫
  • 腫瘍免疫
  • 制御性T細胞
  • IDO
  • 流産
  • 妊娠高血圧症候群
  • 婦人科腫瘍
  • 制御性NK細胞
  • ID0
  • 妊娠
  • 癌
  • 免疫
  • トレランス
  • NK細胞
  • pregnancy
  • tumor
  • immunology
  • regulatory T cell
  • regulatory NK cell
  • tolerance

Access Project

View all 72 Research outputs