Epithelial-to-Mesenchymal Transition and Acquisition of Chemoresistance

  • Toge, Masayoshi (Principal Investigator)
  • 横山, 悟 (Co-Investigator(Renkei-kenkyūsha))
  • 早川, 芳弘 (Co-Investigator(Renkei-kenkyūsha))
  • 済木, 育夫 (Co-Investigator(Renkei-kenkyūsha))

Project Details

Outline of Final Research Achievements

We focused on TGF-b induced epithelial-to-mesenchymal transition (EMT) because it is involved in both metastasis and chemo-resistance and the mechanism of its EMT-related chemo-resistance has not been known. In this study, we identified MCL1 as a critical molecule for TGF-b induced chemo-resistance in NSCLC cells, A549. Moreover, targeting MCL1 using siRNA or pan-BCL2 inhibitor, obatoclax mesylate, could overcome the TGF-b induced chemoresistance. Collectively, TGF-b induced chemo-resistance and MCL-1 itself could provide a new therapeutic opportunity in NSCLC patients even in post-operative chemotherapies.
StatusFinished
Effective start/end date2012/04/01 → 2015/03/31

Funding

  • Japan Society for the Promotion of Science: ¥4,420,000.00

Keywords

  • 上皮間葉転換
  • 抗癌剤耐性
  • Mcl-1
  • 抗癌剤
  • アポトーシス

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