The long-term effects of a Kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination

Ikuo Saiki*, Keiichi Koizumi, Hirozo Goto, Akiko Inujima, Takao Namiki, Masaki Raimura, Toshiaki Kogure, Takeshi Tatsumi, Hiroki Inoue, Shinya Sakai, Hiroshi Oka, Makoto Fujimoto, Hiroaki Hikiami, Hiroaki Sakurai, Naotoshi Shibahara, Yutaka Shimada, Hideki Origasa

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

18 被引用数 (Scopus)

抄録

We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.

本文言語英語
論文番号568074
ジャーナルEvidence-based Complementary and Alternative Medicine
2013
DOI
出版ステータス出版済み - 2013

ASJC Scopus 主題領域

  • 補完代替医療

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