Synthesis of alkynyl C-nucleotide triphosphates toward enzymatic elongation of artificial DNA

Yutaro Oda, Junya Chiba, Masahiko Inouye*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

Four types of alkynyl C-nucleotide triphosphates were synthesized, in which heterocyclic compounds as a non-natural nucleobase were tethered to deoxyribose through acetylene bonds. The non-natural nucleobases are D*, T*, G*, and C*, corresponding to natural A, T, G, and C, respectively, from a hydrogen-bonding pattern of view. All the non-natural triphosphates were found to be a good substrate for terminal deoxynucleotidyl transferase (TdT), a natural nucleic acid-relevant enzyme.

本文言語英語
ページ(範囲)612-620
ページ数9
ジャーナルHeterocycles
97
1
DOI
出版ステータス出版済み - 2018

ASJC Scopus 主題領域

  • 分析化学
  • 薬理学
  • 有機化学

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