Synthesis of alkynyl C-nucleotide triphosphates toward enzymatic elongation of artificial DNA

Yutaro Oda, Junya Chiba, Masahiko Inouye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Four types of alkynyl C-nucleotide triphosphates were synthesized, in which heterocyclic compounds as a non-natural nucleobase were tethered to deoxyribose through acetylene bonds. The non-natural nucleobases are D*, T*, G*, and C*, corresponding to natural A, T, G, and C, respectively, from a hydrogen-bonding pattern of view. All the non-natural triphosphates were found to be a good substrate for terminal deoxynucleotidyl transferase (TdT), a natural nucleic acid-relevant enzyme.

Original languageEnglish
Pages (from-to)612-620
Number of pages9
JournalHeterocycles
Volume97
Issue number1
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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