@article{953eeb040ca341d88d8bc01e0f1cbeed,
title = "Increase in activin βA mRNA in rat hippocampus during long-term potentiation",
abstract = "We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.",
keywords = "Activin, Long-term potentiation, Seizure, Synaptic plasticity, TGF-β superfamily, mRNA differential display",
author = "Kaoru Inokuchi and Akihiko Kato and Keiko Hiraia and Fumio Hishinuma and Maki Inoue and Fumiko Ozawa",
note = "Funding Information: Takahashi for advice on in situ hybridization, T. lto for suggestions on differential display, M. Koike for G6PDH eDNA clone, and M. Takahuhi for enmurugement throughout this work. This work was supported in part by Grant in Aid for Scientific Research on Priority Areas on 'Functional Development of Neural Circuits', the Ministry of Eduattion, Science, Spore and Culture of Japan,",
year = "1996",
month = mar,
day = "11",
doi = "10.1016/0014-5793(96)00135-4",
language = "英語",
volume = "382",
pages = "48--52",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1-2",
}