Increase in activin βA mRNA in rat hippocampus during long-term potentiation

Kaoru Inokuchi; Akihiko Kato; Keiko Hiraia; Fumio Hishinuma; Maki Inoue; Fumiko Ozawa

doi:10.1016/0014-5793(96)00135-4

Increase in activin βA mRNA in rat hippocampus during long-term potentiation

Kaoru Inokuchi^*, Akihiko Kato, Keiko Hiraia, Fumio Hishinuma, Maki Inoue, Fumiko Ozawa

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.

Original language	English
Pages (from-to)	48-52
Number of pages	5
Journal	FEBS Letters
Volume	382
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(96)00135-4
State	Published - 1996/03/11

Keywords

Activin
Long-term potentiation
Seizure
Synaptic plasticity
TGF-β superfamily
mRNA differential display

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(96)00135-4

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title = "Increase in activin βA mRNA in rat hippocampus during long-term potentiation",

abstract = "We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.",

keywords = "Activin, Long-term potentiation, Seizure, Synaptic plasticity, TGF-β superfamily, mRNA differential display",

author = "Kaoru Inokuchi and Akihiko Kato and Keiko Hiraia and Fumio Hishinuma and Maki Inoue and Fumiko Ozawa",

note = "Funding Information: Takahashi for advice on in situ hybridization, T. lto for suggestions on differential display, M. Koike for G6PDH eDNA clone, and M. Takahuhi for enmurugement throughout this work. This work was supported in part by Grant in Aid for Scientific Research on Priority Areas on 'Functional Development of Neural Circuits', the Ministry of Eduattion, Science, Spore and Culture of Japan,",

year = "1996",

month = mar,

day = "11",

doi = "10.1016/0014-5793(96)00135-4",

language = "英語",

volume = "382",

pages = "48--52",

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T1 - Increase in activin βA mRNA in rat hippocampus during long-term potentiation

AU - Inokuchi, Kaoru

AU - Kato, Akihiko

AU - Hiraia, Keiko

AU - Hishinuma, Fumio

AU - Inoue, Maki

AU - Ozawa, Fumiko

N1 - Funding Information: Takahashi for advice on in situ hybridization, T. lto for suggestions on differential display, M. Koike for G6PDH eDNA clone, and M. Takahuhi for enmurugement throughout this work. This work was supported in part by Grant in Aid for Scientific Research on Priority Areas on 'Functional Development of Neural Circuits', the Ministry of Eduattion, Science, Spore and Culture of Japan,

PY - 1996/3/11

Y1 - 1996/3/11

N2 - We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.

AB - We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.

KW - Activin

KW - Long-term potentiation

KW - Seizure

KW - Synaptic plasticity

KW - TGF-β superfamily

KW - mRNA differential display

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U2 - 10.1016/0014-5793(96)00135-4

DO - 10.1016/0014-5793(96)00135-4

M3 - 学術論文

C2 - 8612762

AN - SCOPUS:0029670475

SN - 0014-5793

VL - 382

SP - 48

EP - 52

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Increase in activin βA mRNA in rat hippocampus during long-term potentiation

Abstract

Keywords

ASJC Scopus subject areas

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