Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

Junya Chiba; Ayumi Akaishi; Reona Ikeda; Masahiko Inouye

doi:10.1039/c0cc02371j

Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

Junya Chiba^*, Ayumi Akaishi, Reona Ikeda, Masahiko Inouye

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (SciVal)

抄録

Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.

本文言語	英語
ページ（範囲）	7563-7565
ページ数	3
ジャーナル	Chemical Communications
巻	46
号	40
DOI	https://doi.org/10.1039/c0cc02371j
出版ステータス	出版済み - 2010/10/28

ASJC Scopus 主題領域

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学一般
表面、皮膜および薄膜
金属および合金
材料化学

文献へのアクセス

10.1039/c0cc02371j

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引用スタイル

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AU - Inouye, Masahiko

PY - 2010/10/28

Y1 - 2010/10/28

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AB - Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.

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