Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

Junya Chiba; Ayumi Akaishi; Reona Ikeda; Masahiko Inouye

doi:10.1039/c0cc02371j

Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

Junya Chiba^*, Ayumi Akaishi, Reona Ikeda, Masahiko Inouye

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Abstract

Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.

Original language	English
Pages (from-to)	7563-7565
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	40
DOIs	https://doi.org/10.1039/c0cc02371j
State	Published - 2010/10/28

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc02371j

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abstract = "Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.",

author = "Junya Chiba and Ayumi Akaishi and Reona Ikeda and Masahiko Inouye",

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T1 - Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

AU - Chiba, Junya

AU - Akaishi, Ayumi

AU - Ikeda, Reona

AU - Inouye, Masahiko

PY - 2010/10/28

Y1 - 2010/10/28

N2 - Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.

AB - Ferrocene-modified DNA probes formed fully matched duplexes and bulge-containing ones with wild-type and insertion/deletion-type complements of clinical importance, respectively. Cyclic voltammetry measurements revealed that the bulge-containing duplexes showed an increased flexibility compared to the fully matched duplexes. The difference in the bending elasticity could be read out electrochemically by square wave voltammetry.

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U2 - 10.1039/c0cc02371j

DO - 10.1039/c0cc02371j

M3 - 学術論文

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Electrochemical detection of insertion/deletion mutations based on enhanced flexibility of bulge-containing duplexes on electrodes

Abstract

ASJC Scopus subject areas

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