Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

Etsuro Hori; Hideo Shojaku; Naoto Watanabe; Yasuhiro Kawasaki; Michio Suzuki; Mariana F.P. de Araujo; Yoshinao Nagashima; Yukihiro Yada; Taketoshi Ono; Hisao Nishijo

doi:10.1016/j.autneu.2012.01.010

Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

Etsuro Hori, Hideo Shojaku, Naoto Watanabe, Yasuhiro Kawasaki, Michio Suzuki, Mariana F.P. de Araujo, Yoshinao Nagashima, Yukihiro Yada, Taketoshi Ono, Hisao Nishijo^*

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

抄録

A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

本文言語	英語
ページ（範囲）	88-92
ページ数	5
ジャーナル	Autonomic Neuroscience: Basic and Clinical
巻	168
号	1-2
DOI	https://doi.org/10.1016/j.autneu.2012.01.010
出版ステータス	出版済み - 2012/05/21

ASJC Scopus 主題領域

内分泌系および自律システム
臨床神経学
細胞および分子神経科学

文献へのアクセス

10.1016/j.autneu.2012.01.010

引用スタイル

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title = "Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects",

abstract = "A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.",

keywords = "Amygdala, Autonomic nervous system, Heart rate, Hippocampus, Vagal nerve",

author = "Etsuro Hori and Hideo Shojaku and Naoto Watanabe and Yasuhiro Kawasaki and Michio Suzuki and {de Araujo}, {Mariana F.P.} and Yoshinao Nagashima and Yukihiro Yada and Taketoshi Ono and Hisao Nishijo",

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doi = "10.1016/j.autneu.2012.01.010",

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TY - JOUR

T1 - Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

AU - Hori, Etsuro

AU - Shojaku, Hideo

AU - Watanabe, Naoto

AU - Kawasaki, Yasuhiro

AU - Suzuki, Michio

AU - de Araujo, Mariana F.P.

AU - Nagashima, Yoshinao

AU - Yada, Yukihiro

AU - Ono, Taketoshi

AU - Nishijo, Hisao

PY - 2012/5/21

Y1 - 2012/5/21

N2 - A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

AB - A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

KW - Amygdala

KW - Autonomic nervous system

KW - Heart rate

KW - Hippocampus

KW - Vagal nerve

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U2 - 10.1016/j.autneu.2012.01.010

DO - 10.1016/j.autneu.2012.01.010

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AN - SCOPUS:84862813076

SN - 1566-0702

VL - 168

SP - 88

EP - 92

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

IS - 1-2

ER -

Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

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ASJC Scopus 主題領域

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