Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

Etsuro Hori; Hideo Shojaku; Naoto Watanabe; Yasuhiro Kawasaki; Michio Suzuki; Mariana F.P. de Araujo; Yoshinao Nagashima; Yukihiro Yada; Taketoshi Ono; Hisao Nishijo

doi:10.1016/j.autneu.2012.01.010

Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

Etsuro Hori, Hideo Shojaku, Naoto Watanabe, Yasuhiro Kawasaki, Michio Suzuki, Mariana F.P. de Araujo, Yoshinao Nagashima, Yukihiro Yada, Taketoshi Ono, Hisao Nishijo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

Original language	English
Pages (from-to)	88-92
Number of pages	5
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2012.01.010
State	Published - 2012/05/21

Keywords

Amygdala
Autonomic nervous system
Heart rate
Hippocampus
Vagal nerve

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1016/j.autneu.2012.01.010

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title = "Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects",

abstract = "A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.",

keywords = "Amygdala, Autonomic nervous system, Heart rate, Hippocampus, Vagal nerve",

author = "Etsuro Hori and Hideo Shojaku and Naoto Watanabe and Yasuhiro Kawasaki and Michio Suzuki and {de Araujo}, {Mariana F.P.} and Yoshinao Nagashima and Yukihiro Yada and Taketoshi Ono and Hisao Nishijo",

year = "2012",

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doi = "10.1016/j.autneu.2012.01.010",

language = "英語",

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pages = "88--92",

journal = "Autonomic Neuroscience: Basic and Clinical",

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TY - JOUR

T1 - Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

AU - Hori, Etsuro

AU - Shojaku, Hideo

AU - Watanabe, Naoto

AU - Kawasaki, Yasuhiro

AU - Suzuki, Michio

AU - de Araujo, Mariana F.P.

AU - Nagashima, Yoshinao

AU - Yada, Yukihiro

AU - Ono, Taketoshi

AU - Nishijo, Hisao

PY - 2012/5/21

Y1 - 2012/5/21

N2 - A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

AB - A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.

KW - Amygdala

KW - Autonomic nervous system

KW - Heart rate

KW - Hippocampus

KW - Vagal nerve

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SN - 1566-0702

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JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

IS - 1-2

ER -

Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects

Abstract

Keywords

ASJC Scopus subject areas

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