Does autophagy work in synaptic plasticity and memory?

Mohammad Shehata, Kaoru Inokuchi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

29 被引用数 (Scopus)

抄録

Many studies have reported the roles played by regulated proteolysis in neural plasticity and memory. Within this context, most of the research focused on the ubiquitin-proteasome system and the endosome-lysosome system while giving lesser consideration to another major protein degradation system, namely, autophagy. Although autophagy intersects with many of the pathways known to underlie synaptic plasticity and memory, only few reports related autophagy to synaptic remodeling. These pathways include PI3K-mTOR pathway and endosome- dependent proteolysis. In this review, we will discuss several lines of evidence supporting a physiological role of autophagy in memory processes, and the possible mechanistic scenarios for how autophagy could fulfill this function.

本文言語英語
ページ(範囲)543-557
ページ数15
ジャーナルReviews in the Neurosciences
25
4
DOI
出版ステータス出版済み - 2014/08/01

ASJC Scopus 主題領域

  • 神経科学一般

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