抄録
– A heterocyclic compound, 2-aminopyrimidin-4-one, was found to be a new candidate of a non-natural nucleobase that forms a novel base pair by self-dimerization. 2-Aminopyrimidin-4-one was connected to a deoxyribose through an acetylene linkage. The non-natural nucleoside was derivatized to its phosphoramidite that could be subjected to a conventional solid-phase DNA synthesis. The solid-phase auto-synthesis successfully afforded a non-natural DNA-like oligomer bearing 2-aminopyrimidin-4-one as a nucleobase. The synthetic oligomer exhibited reversible formation of a higher-order structure that would be a duplex like natural DNA. The present study means creation of a novel artificial DNA-like system with unordinary odd numbers of genetic alphabets.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1149-1156 |
ページ数 | 8 |
ジャーナル | Heterocycles |
巻 | 97 |
号 | 2 |
DOI | |
出版ステータス | 出版済み - 2018 |
ASJC Scopus 主題領域
- 分析化学
- 薬理学
- 有機化学