Abstract
– A heterocyclic compound, 2-aminopyrimidin-4-one, was found to be a new candidate of a non-natural nucleobase that forms a novel base pair by self-dimerization. 2-Aminopyrimidin-4-one was connected to a deoxyribose through an acetylene linkage. The non-natural nucleoside was derivatized to its phosphoramidite that could be subjected to a conventional solid-phase DNA synthesis. The solid-phase auto-synthesis successfully afforded a non-natural DNA-like oligomer bearing 2-aminopyrimidin-4-one as a nucleobase. The synthetic oligomer exhibited reversible formation of a higher-order structure that would be a duplex like natural DNA. The present study means creation of a novel artificial DNA-like system with unordinary odd numbers of genetic alphabets.
Original language | English |
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Pages (from-to) | 1149-1156 |
Number of pages | 8 |
Journal | Heterocycles |
Volume | 97 |
Issue number | 2 |
DOIs | |
State | Published - 2018 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry