Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

J. Chiba; S. Aoki; J. Yamamoto; S. Iwai; M. Inouye

doi:10.1039/c4cc04513k

Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

J. Chiba^*, S. Aoki, J. Yamamoto, S. Iwai, M. Inouye

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研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

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We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

本文言語	英語
ページ（範囲）	11126-11128
ページ数	3
ジャーナル	Chemical Communications
巻	50
号	76
DOI	https://doi.org/10.1039/c4cc04513k
出版ステータス	出版済み - 2014/08/26

ASJC Scopus 主題領域

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学一般
表面、皮膜および薄膜
金属および合金
材料化学

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10.1039/c4cc04513k

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title = "Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes",

abstract = "We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.",

author = "J. Chiba and S. Aoki and J. Yamamoto and S. Iwai and M. Inouye",

year = "2014",

month = aug,

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doi = "10.1039/c4cc04513k",

language = "英語",

volume = "50",

pages = "11126--11128",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

AU - Chiba, J.

AU - Aoki, S.

AU - Yamamoto, J.

AU - Iwai, S.

AU - Inouye, M.

PY - 2014/8/26

Y1 - 2014/8/26

N2 - We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

AB - We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

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U2 - 10.1039/c4cc04513k

DO - 10.1039/c4cc04513k

M3 - 学術論文

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SN - 1359-7345

VL - 50

SP - 11126

EP - 11128

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

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