Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

J. Chiba; S. Aoki; J. Yamamoto; S. Iwai; M. Inouye

doi:10.1039/c4cc04513k

Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

J. Chiba^*, S. Aoki, J. Yamamoto, S. Iwai, M. Inouye

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

Original language	English
Pages (from-to)	11126-11128
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	76
DOIs	https://doi.org/10.1039/c4cc04513k
State	Published - 2014/08/26

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.",

author = "J. Chiba and S. Aoki and J. Yamamoto and S. Iwai and M. Inouye",

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T1 - Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

AU - Chiba, J.

AU - Aoki, S.

AU - Yamamoto, J.

AU - Iwai, S.

AU - Inouye, M.

PY - 2014/8/26

Y1 - 2014/8/26

N2 - We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

AB - We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

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U2 - 10.1039/c4cc04513k

DO - 10.1039/c4cc04513k

M3 - 学術論文

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SP - 11126

EP - 11128

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

Abstract

ASJC Scopus subject areas

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