TY - JOUR
T1 - Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme
AU - Gulshan, Ara
AU - Matsumura, Shigeyoshi
AU - Higuchi, Tsunehiko
AU - Umezawa, Naoki
AU - Ikawa, Yoshiya
N1 - Publisher Copyright:
© 2018 Japan society for Bioscience, Biotechnology, and agrochemistry
PY - 2018
Y1 - 2018
N2 - Polyamines are a promising class of molecules that can modulate RNA enzyme activities. To analyze the effects of the number of amine moieties systematically, we employed four polyamines sharing dimethylene units to connect amine moieties. As a model RNA enzyme, we used a structurally unstable group I ribozyme, which was activated most and least efficiently by tetraethylenepentamine and diethylenetriamine respectively.
AB - Polyamines are a promising class of molecules that can modulate RNA enzyme activities. To analyze the effects of the number of amine moieties systematically, we employed four polyamines sharing dimethylene units to connect amine moieties. As a model RNA enzyme, we used a structurally unstable group I ribozyme, which was activated most and least efficiently by tetraethylenepentamine and diethylenetriamine respectively.
KW - Group i intron
KW - Polyamine
KW - Polyethylene polyamine
KW - Ribozyme
UR - http://www.scopus.com/inward/record.url?scp=85052021489&partnerID=8YFLogxK
U2 - 10.1080/09168451.2018.1465811
DO - 10.1080/09168451.2018.1465811
M3 - 学術論文
C2 - 29699448
AN - SCOPUS:85052021489
SN - 0916-8451
VL - 82
SP - 1404
EP - 1407
JO - Bioscience, biotechnology, and biochemistry
JF - Bioscience, biotechnology, and biochemistry
IS - 8
ER -