TY - JOUR
T1 - Cerebral glucose metabolism associated with a fear network in panic disorder
AU - Sakai, Yojiro
AU - Kumano, Hiroaki
AU - Nishikawa, Masami
AU - Sakano, Yuji
AU - Kaiya, Hisanobu
AU - Imabayashi, Etsuko
AU - Ohnishi, Takashi
AU - Matsuda, Hiroshi
AU - Yasuda, Asako
AU - Sato, Atsushi
AU - Diksic, Mirko
AU - Kuboki, Tomifusa
PY - 2005/6/21
Y1 - 2005/6/21
N2 - The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.
AB - The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.
KW - Amygdala
KW - Anticipatory anxiety
KW - Fear network
KW - Panic attack
KW - Panic disorder
KW - Positron emission tomography
KW - Regional brain glucose metabolism
UR - http://www.scopus.com/inward/record.url?scp=21344436372&partnerID=8YFLogxK
U2 - 10.1097/00001756-200506210-00010
DO - 10.1097/00001756-200506210-00010
M3 - 学術論文
C2 - 15931063
AN - SCOPUS:21344436372
SN - 0959-4965
VL - 16
SP - 927
EP - 931
JO - NeuroReport
JF - NeuroReport
IS - 9
ER -
