Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate

Hisatomo Suzuki, Lifu Li, Tadashi Nakaji-Hirabayashi, Hiromi Kitano*, Kohji Ohno, Kazuyoshi Matsuoka, Yoshiyuki Saruwatari

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

16 被引用数 (Scopus)

抄録

A random copolymer of zwitterionic monomer, carboxymethylbetaine (CMB), and 3-methacryloyloxypropyl trimethoxysilane was prepared in ethanol using 2,2'-azobisisobutyronitrile as initiator. The incubation of ethanol solution of the copolymer with a glass plate gave a layer of the copolymer with a thickness of about 2-3. nm. The copolymer-modified glass substrate became highly hydrophilic upon immersion in water, and showed a resistance against non-specific adsorption of proteins, and the degree of resistance increased with the content of CMB residues in the copolymer and leveled off. The adhesion of various cells to the glass substrate was also strongly suppressed by the surface modification with the copolymer layer. Further introduction of PolyCMB graft chains on the surface of the layer enhanced the suppression of cell adhesion due to the steric hindrance for the cells to approach the layer. The usefulness of the combination of zwitterionic polymer layer and graft chains to afford anti-biofouling properties to a solid surface of metal oxides was shown.

本文言語英語
ページ(範囲)107-113
ページ数7
ジャーナルColloids and Surfaces B: Biointerfaces
94
DOI
出版ステータス出版済み - 2012/06/01

ASJC Scopus 主題領域

  • バイオテクノロジー
  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

フィンガープリント

「Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル