Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Yasuhiro Igarashi; Tsukasa Mogi; Saeko Yanase; Satoshi Miyanaga; Tsuyoshi Fujita; Hiroaki Sakurai; Ikuo Saiki; Ayumi Ohsaki

doi:10.1021/np9000575

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Yasuhiro Igarashi^*, Tsukasa Mogi, Saeko Yanase, Satoshi Miyanaga, Tsuyoshi Fujita, Hiroaki Sakurai, Ikuo Saiki, Ayumi Ohsaki

^*この論文の責任著者

がん細胞生物学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

47 被引用数 (Scopus)

抄録

Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC₅₀ value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

本文言語	英語
ページ（範囲）	980-982
ページ数	3
ジャーナル	Journal of Natural Products
巻	72
号	5
DOI	https://doi.org/10.1021/np9000575
出版ステータス	出版済み - 2009/05/22

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/np9000575

引用スタイル

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abstract = "Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.",

author = "Yasuhiro Igarashi and Tsukasa Mogi and Saeko Yanase and Satoshi Miyanaga and Tsuyoshi Fujita and Hiroaki Sakurai and Ikuo Saiki and Ayumi Ohsaki",

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T1 - Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

AU - Igarashi, Yasuhiro

AU - Mogi, Tsukasa

AU - Yanase, Saeko

AU - Miyanaga, Satoshi

AU - Fujita, Tsuyoshi

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Ohsaki, Ayumi

PY - 2009/5/22

Y1 - 2009/5/22

N2 - Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

AB - Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

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U2 - 10.1021/np9000575

DO - 10.1021/np9000575

M3 - 学術論文

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Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

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