Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Yasuhiro Igarashi; Tsukasa Mogi; Saeko Yanase; Satoshi Miyanaga; Tsuyoshi Fujita; Hiroaki Sakurai; Ikuo Saiki; Ayumi Ohsaki

doi:10.1021/np9000575

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Yasuhiro Igarashi^*, Tsukasa Mogi, Saeko Yanase, Satoshi Miyanaga, Tsuyoshi Fujita, Hiroaki Sakurai, Ikuo Saiki, Ayumi Ohsaki

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC₅₀ value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

Original language	English
Pages (from-to)	980-982
Number of pages	3
Journal	Journal of Natural Products
Volume	72
Issue number	5
DOIs	https://doi.org/10.1021/np9000575
State	Published - 2009/05/22

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9000575

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title = "Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.",

abstract = "Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.",

author = "Yasuhiro Igarashi and Tsukasa Mogi and Saeko Yanase and Satoshi Miyanaga and Tsuyoshi Fujita and Hiroaki Sakurai and Ikuo Saiki and Ayumi Ohsaki",

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T1 - Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

AU - Igarashi, Yasuhiro

AU - Mogi, Tsukasa

AU - Yanase, Saeko

AU - Miyanaga, Satoshi

AU - Fujita, Tsuyoshi

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Ohsaki, Ayumi

PY - 2009/5/22

Y1 - 2009/5/22

N2 - Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

AB - Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC50 value of 0.39 μM in a concentration-dependent manner without showing cytotoxic effects.

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U2 - 10.1021/np9000575

DO - 10.1021/np9000575

M3 - 学術論文

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Abstract

ASJC Scopus subject areas

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