抄録
Naturally occurring ribozymes with defined three-dimensional (3D) structures serve as promising platforms for the design and construction of artificial RNA nanostructures. We constructed a hexameric ribozyme nanostructure by face-to-face dimerization of a pair of triangular ribozyme trimers, unit RNAs of which were derived from the Tetrahymena group I ribozyme. In this study, we have expanded the dimerization strategy to a square-shaped ribozyme tetramer by introducing four pillar units. The resulting box-shaped nanostructures, which contained eight ribozyme units, can be assembled from either four or two components of their unit RNAs.
本文言語 | 英語 |
---|---|
ページ(範囲) | 195-202 |
ページ数 | 8 |
ジャーナル | Journal of Bioscience and Bioengineering |
巻 | 134 |
号 | 3 |
DOI | |
出版ステータス | 出版済み - 2022/09 |
ASJC Scopus 主題領域
- バイオテクノロジー
- バイオエンジニアリング
- 応用微生物学とバイオテクノロジー