Augmentation of allergic reactions by several pesticides

Takahiko Sato; Masato Taguchi; Hisamitsu Nagase; Hideaki Kito; Miki Niikawa

doi:10.1016/S0300-483X(97)00184-4

Augmentation of allergic reactions by several pesticides

Takahiko Sato, Masato Taguchi, Hisamitsu Nagase^*, Hideaki Kito, Miki Niikawa

^*この論文の責任著者

実践薬学（薬学）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

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The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.

本文言語	英語
ページ（範囲）	41-53
ページ数	13
ジャーナル	Toxicology
巻	126
号	1
DOI	https://doi.org/10.1016/S0300-483X(97)00184-4
出版ステータス	出版済み - 1998/02/20

ASJC Scopus 主題領域

毒物学

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10.1016/S0300-483X(97)00184-4

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title = "Augmentation of allergic reactions by several pesticides",

abstract = "The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.",

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AU - Sato, Takahiko

AU - Taguchi, Masato

AU - Nagase, Hisamitsu

AU - Kito, Hideaki

AU - Niikawa, Miki

PY - 1998/2/20

Y1 - 1998/2/20

N2 - The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.

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KW - Mast cells

KW - PCA

KW - Passive cutaneous anaphylaxis

KW - Pesticides

KW - TNF-α

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Augmentation of allergic reactions by several pesticides

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