Augmentation of allergic reactions by several pesticides

Takahiko Sato; Masato Taguchi; Hisamitsu Nagase; Hideaki Kito; Miki Niikawa

doi:10.1016/S0300-483X(97)00184-4

Augmentation of allergic reactions by several pesticides

Takahiko Sato, Masato Taguchi, Hisamitsu Nagase^*, Hideaki Kito, Miki Niikawa

^*Corresponding author for this work

Laboratory of Pharmacy Practice and Sciences

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.

Original language	English
Pages (from-to)	41-53
Number of pages	13
Journal	Toxicology
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/S0300-483X(97)00184-4
State	Published - 1998/02/20

Keywords

Histamine release
Mast cells
PCA
Passive cutaneous anaphylaxis
Pesticides
TNF-α

ASJC Scopus subject areas

Toxicology

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10.1016/S0300-483X(97)00184-4

Cite this

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title = "Augmentation of allergic reactions by several pesticides",

abstract = "The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.",

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AU - Sato, Takahiko

AU - Taguchi, Masato

AU - Nagase, Hisamitsu

AU - Kito, Hideaki

AU - Niikawa, Miki

PY - 1998/2/20

Y1 - 1998/2/20

N2 - The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.

AB - The augmentative effects of several pesticides on histamine release from mast cells of rats that had been sensitized passively by anti-dinitrophenol (DNP) monoclonal IgE antibodies were investigated in vitro. Various pesticides, especially phenthoate (PAP), chlornitrofen (CNP) and paraquat (PQ), increased histamine release. This increase was not observed in histamine release with non-antigen or induction by calcium ionophore A23187 or compound 48/80. Passive cutaneous anaphylaxis (PCA) was examined, and an increase of PCA was observed with PAP and PQ, but not with CNP, while an increase of tumor necrosis factor-α (TNF-α) production was observed with CNP and PQ, but not PAP. These results suggest that various pesticides as environmental pollutants exacerbate allergic diseases.

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KW - Mast cells

KW - PCA

KW - Passive cutaneous anaphylaxis

KW - Pesticides

KW - TNF-α

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Augmentation of allergic reactions by several pesticides

Abstract

Keywords

ASJC Scopus subject areas

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