Artificial DNA made exclusively of nonnatural C-nucleosides with four types of nonnatural bases

Yasuhiro Doi, Junya Chiba*, Tomoyuki Morikawa, Masahiko Inouye

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

65 被引用数 (Scopus)

抄録

We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.

本文言語英語
ページ(範囲)8762-8768
ページ数7
ジャーナルJournal of the American Chemical Society
130
27
DOI
出版ステータス出版済み - 2008/07/09

ASJC Scopus 主題領域

  • 触媒
  • 化学一般
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

「Artificial DNA made exclusively of nonnatural C-nucleosides with four types of nonnatural bases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル