抄録
We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.
本文言語 | 英語 |
---|---|
ページ(範囲) | 8762-8768 |
ページ数 | 7 |
ジャーナル | Journal of the American Chemical Society |
巻 | 130 |
号 | 27 |
DOI | |
出版ステータス | 出版済み - 2008/07/09 |
ASJC Scopus 主題領域
- 触媒
- 化学一般
- 生化学
- コロイド化学および表面化学