Artificial DNA made exclusively of nonnatural C-nucleosides with four types of nonnatural bases

Yasuhiro Doi; Junya Chiba; Tomoyuki Morikawa; Masahiko Inouye

doi:10.1021/ja801058h

Artificial DNA made exclusively of nonnatural C-nucleosides with four types of nonnatural bases

Yasuhiro Doi, Junya Chiba^*, Tomoyuki Morikawa, Masahiko Inouye

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.

Original language	English
Pages (from-to)	8762-8768
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	130
Issue number	27
DOIs	https://doi.org/10.1021/ja801058h
State	Published - 2008/07/09

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.",

author = "Yasuhiro Doi and Junya Chiba and Tomoyuki Morikawa and Masahiko Inouye",

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AU - Morikawa, Tomoyuki

AU - Inouye, Masahiko

PY - 2008/7/9

Y1 - 2008/7/9

N2 - We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.

AB - We describe a new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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ER -

Artificial DNA made exclusively of nonnatural C-nucleosides with four types of nonnatural bases

Abstract

ASJC Scopus subject areas

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