Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

Yasuhiro Igarashi; Linkai Yu; Satoshi Miyanaga; Takao Fukuda; Noriko Saitoh; Hiroaki Sakurai; Ikuo Saiki; Pablo Alonso-Vega; Martha E. Trujillo

doi:10.1021/np100292h

Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

Yasuhiro Igarashi^*, Linkai Yu, Satoshi Miyanaga, Takao Fukuda, Noriko Saitoh, Hiroaki Sakurai, Ikuo Saiki, Pablo Alonso-Vega, Martha E. Trujillo

^*この論文の責任著者

がん細胞生物学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

45 被引用数 (Scopus)

抄録

Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC₅₀ values of 11 and 0.21 μM, respectively.

本文言語	英語
ページ（範囲）	1943-1946
ページ数	4
ジャーナル	Journal of Natural Products
巻	73
号	11
DOI	https://doi.org/10.1021/np100292h
出版ステータス	出版済み - 2010/11/29

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/np100292h

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title = "Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39",

abstract = "Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.",

author = "Yasuhiro Igarashi and Linkai Yu and Satoshi Miyanaga and Takao Fukuda and Noriko Saitoh and Hiroaki Sakurai and Ikuo Saiki and Pablo Alonso-Vega and Trujillo, {Martha E.}",

year = "2010",

month = nov,

day = "29",

doi = "10.1021/np100292h",

language = "英語",

volume = "73",

pages = "1943--1946",

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T1 - Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

AU - Igarashi, Yasuhiro

AU - Yu, Linkai

AU - Miyanaga, Satoshi

AU - Fukuda, Takao

AU - Saitoh, Noriko

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Alonso-Vega, Pablo

AU - Trujillo, Martha E.

PY - 2010/11/29

Y1 - 2010/11/29

N2 - Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.

AB - Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.

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U2 - 10.1021/np100292h

DO - 10.1021/np100292h

M3 - 学術論文

C2 - 21028891

AN - SCOPUS:78650186701

SN - 0163-3864

VL - 73

SP - 1943

EP - 1946

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

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ASJC Scopus 主題領域

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