Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

Yasuhiro Igarashi; Linkai Yu; Satoshi Miyanaga; Takao Fukuda; Noriko Saitoh; Hiroaki Sakurai; Ikuo Saiki; Pablo Alonso-Vega; Martha E. Trujillo

doi:10.1021/np100292h

Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

Yasuhiro Igarashi^*, Linkai Yu, Satoshi Miyanaga, Takao Fukuda, Noriko Saitoh, Hiroaki Sakurai, Ikuo Saiki, Pablo Alonso-Vega, Martha E. Trujillo

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC₅₀ values of 11 and 0.21 μM, respectively.

Original language	English
Pages (from-to)	1943-1946
Number of pages	4
Journal	Journal of Natural Products
Volume	73
Issue number	11
DOIs	https://doi.org/10.1021/np100292h
State	Published - 2010/11/29

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39",

abstract = "Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.",

author = "Yasuhiro Igarashi and Linkai Yu and Satoshi Miyanaga and Takao Fukuda and Noriko Saitoh and Hiroaki Sakurai and Ikuo Saiki and Pablo Alonso-Vega and Trujillo, {Martha E.}",

year = "2010",

month = nov,

day = "29",

doi = "10.1021/np100292h",

language = "英語",

volume = "73",

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journal = "Journal of Natural Products",

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T1 - Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

AU - Igarashi, Yasuhiro

AU - Yu, Linkai

AU - Miyanaga, Satoshi

AU - Fukuda, Takao

AU - Saitoh, Noriko

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Alonso-Vega, Pablo

AU - Trujillo, Martha E.

PY - 2010/11/29

Y1 - 2010/11/29

N2 - Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.

AB - Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 μM, respectively.

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U2 - 10.1021/np100292h

DO - 10.1021/np100292h

M3 - 学術論文

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AN - SCOPUS:78650186701

SN - 0163-3864

VL - 73

SP - 1943

EP - 1946

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Abyssomicin I, a modified polycyclic polyketide from streptomyces sp. CHI39

Abstract

ASJC Scopus subject areas

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