Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

Satoshi Miyanaga; Takamasa Obata; Hiroyasu Onaka; Tsuyoshi Fujita; Noriko Saito; Hiroaki Sakurai; Ikuo Saiki; Tamotsu Furumai; Yasuhiro Igarashi

doi:10.1038/ja.2006.93

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

Satoshi Miyanaga, Takamasa Obata, Hiroyasu Onaka, Tsuyoshi Fujita, Noriko Saito, Hiroaki Sakurai, Ikuo Saiki, Tamotsu Furumai, Yasuhiro Igarashi^*

^*この論文の責任著者

がん細胞生物学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

47 被引用数 (Scopus)

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In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

本文言語	英語
ページ（範囲）	698-703
ページ数	6
ジャーナル	Journal of Antibiotics
巻	59
号	11
DOI	https://doi.org/10.1038/ja.2006.93
出版ステータス	出版済み - 2006/11

ASJC Scopus 主題領域

薬理学
創薬

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10.1038/ja.2006.93

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title = "Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861",

abstract = "In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.",

keywords = "Antitumor, Invasion, Myxochelin A, Nonomuraea",

author = "Satoshi Miyanaga and Takamasa Obata and Hiroyasu Onaka and Tsuyoshi Fujita and Noriko Saito and Hiroaki Sakurai and Ikuo Saiki and Tamotsu Furumai and Yasuhiro Igarashi",

year = "2006",

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doi = "10.1038/ja.2006.93",

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T1 - Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

AU - Miyanaga, Satoshi

AU - Obata, Takamasa

AU - Onaka, Hiroyasu

AU - Fujita, Tsuyoshi

AU - Saito, Noriko

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Furumai, Tamotsu

AU - Igarashi, Yasuhiro

PY - 2006/11

Y1 - 2006/11

N2 - In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

AB - In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

KW - Antitumor

KW - Invasion

KW - Myxochelin A

KW - Nonomuraea

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U2 - 10.1038/ja.2006.93

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M3 - 学術論文

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SN - 0021-8820

VL - 59

SP - 698

EP - 703

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 11

ER -

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

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