Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

Satoshi Miyanaga; Takamasa Obata; Hiroyasu Onaka; Tsuyoshi Fujita; Noriko Saito; Hiroaki Sakurai; Ikuo Saiki; Tamotsu Furumai; Yasuhiro Igarashi

doi:10.1038/ja.2006.93

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

Satoshi Miyanaga, Takamasa Obata, Hiroyasu Onaka, Tsuyoshi Fujita, Noriko Saito, Hiroaki Sakurai, Ikuo Saiki, Tamotsu Furumai, Yasuhiro Igarashi^*

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

Original language	English
Pages (from-to)	698-703
Number of pages	6
Journal	Journal of Antibiotics
Volume	59
Issue number	11
DOIs	https://doi.org/10.1038/ja.2006.93
State	Published - 2006/11

Keywords

Antitumor
Invasion
Myxochelin A
Nonomuraea

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2006.93

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title = "Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861",

abstract = "In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.",

keywords = "Antitumor, Invasion, Myxochelin A, Nonomuraea",

author = "Satoshi Miyanaga and Takamasa Obata and Hiroyasu Onaka and Tsuyoshi Fujita and Noriko Saito and Hiroaki Sakurai and Ikuo Saiki and Tamotsu Furumai and Yasuhiro Igarashi",

year = "2006",

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T1 - Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

AU - Miyanaga, Satoshi

AU - Obata, Takamasa

AU - Onaka, Hiroyasu

AU - Fujita, Tsuyoshi

AU - Saito, Noriko

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Furumai, Tamotsu

AU - Igarashi, Yasuhiro

PY - 2006/11

Y1 - 2006/11

N2 - In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

AB - In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

KW - Antitumor

KW - Invasion

KW - Myxochelin A

KW - Nonomuraea

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SN - 0021-8820

VL - 59

SP - 698

EP - 703

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 11

ER -

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861

Abstract

Keywords

ASJC Scopus subject areas

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