Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Takahiro Mori; Yu Nakashima; Heping Chen; Shotaro Hoshino; Takaaki Mitsuhashi; Ikuro Abe

doi:10.1039/d2cc00736c

Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Takahiro Mori^*, Yu Nakashima, Heping Chen, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

抄録

Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

本文言語	英語
ページ（範囲）	5510-5513
ページ数	4
ジャーナル	Chemical Communications
巻	58
号	36
DOI	https://doi.org/10.1039/d2cc00736c
出版ステータス	出版済み - 2022/04/11

ASJC Scopus 主題領域

電子材料、光学材料、および磁性材料
触媒
セラミックおよび複合材料
化学一般
表面、皮膜および薄膜
金属および合金
材料化学

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10.1039/d2cc00736c

引用スタイル

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abstract = "Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.",

author = "Takahiro Mori and Yu Nakashima and Heping Chen and Shotaro Hoshino and Takaaki Mitsuhashi and Ikuro Abe",

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doi = "10.1039/d2cc00736c",

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AU - Mori, Takahiro

AU - Nakashima, Yu

AU - Chen, Heping

AU - Hoshino, Shotaro

AU - Mitsuhashi, Takaaki

AU - Abe, Ikuro

PY - 2022/4/11

Y1 - 2022/4/11

N2 - Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

AB - Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

UR - http://www.scopus.com/inward/record.url?scp=85129493562&partnerID=8YFLogxK

U2 - 10.1039/d2cc00736c

DO - 10.1039/d2cc00736c

M3 - 学術論文

C2 - 35420093

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SN - 1359-7345

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SP - 5510

EP - 5513

JO - Chemical Communications

JF - Chemical Communications

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Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

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