Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose

Yasuhiro Tsuji; Masato Tashiro; Nobuyuki Ashizawa; Yukio Ota; Hayato Obi; Saori Nagura; Munetoshi Narukawa; Kazuaki Fukahara; Naoki Yoshimura; Hideto To; Yoshihiro Yamamoto

doi:10.2169/internalmedicine.54.2292

Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose

Yasuhiro Tsuji, Masato Tashiro, Nobuyuki Ashizawa, Yukio Ota, Hayato Obi, Saori Nagura, Munetoshi Narukawa, Kazuaki Fukahara, Naoki Yoshimura, Hideto To, Yoshihiro Yamamoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.

Original language	English
Pages (from-to)	235-239
Number of pages	5
Journal	Internal Medicine
Volume	54
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.54.2292
State	Published - 2015/01/15

Keywords

Linezolid
Mediastinitis
Methicillin-resistant Staphylococcus aureus
Renal dysfunction
Therapeutic drug monitoring

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.54.2292

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Tsuji, Y., Tashiro, M., Ashizawa, N., Ota, Y., Obi, H., Nagura, S., Narukawa, M., Fukahara, K., Yoshimura, N., To, H., & Yamamoto, Y. (2015). Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose. Internal Medicine, 54(2), 235-239. https://doi.org/10.2169/internalmedicine.54.2292

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abstract = "This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.",

keywords = "Linezolid, Mediastinitis, Methicillin-resistant Staphylococcus aureus, Renal dysfunction, Therapeutic drug monitoring",

author = "Yasuhiro Tsuji and Masato Tashiro and Nobuyuki Ashizawa and Yukio Ota and Hayato Obi and Saori Nagura and Munetoshi Narukawa and Kazuaki Fukahara and Naoki Yoshimura and Hideto To and Yoshihiro Yamamoto",

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doi = "10.2169/internalmedicine.54.2292",

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Tsuji, Y, Tashiro, M, Ashizawa, N, Ota, Y, Obi, H, Nagura, S, Narukawa, M, Fukahara, K, Yoshimura, N , To, H & Yamamoto, Y 2015, 'Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose', Internal Medicine, vol. 54, no. 2, pp. 235-239. https://doi.org/10.2169/internalmedicine.54.2292

TY - JOUR

T1 - Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose

AU - Tsuji, Yasuhiro

AU - Tashiro, Masato

AU - Ashizawa, Nobuyuki

AU - Ota, Yukio

AU - Obi, Hayato

AU - Nagura, Saori

AU - Narukawa, Munetoshi

AU - Fukahara, Kazuaki

AU - Yoshimura, Naoki

AU - To, Hideto

AU - Yamamoto, Yoshihiro

PY - 2015/1/15

Y1 - 2015/1/15

N2 - This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.

AB - This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.

KW - Linezolid

KW - Mediastinitis

KW - Methicillin-resistant Staphylococcus aureus

KW - Renal dysfunction

KW - Therapeutic drug monitoring

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U2 - 10.2169/internalmedicine.54.2292

DO - 10.2169/internalmedicine.54.2292

M3 - 学術論文

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AN - SCOPUS:84921280493

SN - 0918-2918

VL - 54

SP - 235

EP - 239

JO - Internal Medicine

JF - Internal Medicine

IS - 2

ER -

Treatment of mediastinitis due to methicillin-resistant staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose

Abstract

Keywords

ASJC Scopus subject areas

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