Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Tomoyuki Yoshida; Shuya Fukai

doi:10.1038/srep09686

Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata, Yusuke Sato, Sakurako Goto-Ito, Takeshi Uemura, Asami Maeda, Tomoko Shiroshima, Tomoyuki Yoshida, Shuya Fukai^*

^*Corresponding author for this work

Molecular Neuroscience

Research output: Contribution to journal › Article › peer-review

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Abstract

Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

Original language	English
Article number	9686
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep09686
State	Published - 2015/05/19

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title = "Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion",

abstract = "Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.",

author = "Atsushi Yamagata and Yusuke Sato and Sakurako Goto-Ito and Takeshi Uemura and Asami Maeda and Tomoko Shiroshima and Tomoyuki Yoshida and Shuya Fukai",

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doi = "10.1038/srep09686",

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T1 - Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

AU - Yamagata, Atsushi

AU - Sato, Yusuke

AU - Goto-Ito, Sakurako

AU - Uemura, Takeshi

AU - Maeda, Asami

AU - Shiroshima, Tomoko

AU - Yoshida, Tomoyuki

AU - Fukai, Shuya

PY - 2015/5/19

Y1 - 2015/5/19

N2 - Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

AB - Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

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U2 - 10.1038/srep09686

DO - 10.1038/srep09686

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JO - Scientific Reports

JF - Scientific Reports

M1 - 9686

ER -

Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Abstract

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