Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Tomoyuki Yoshida; Shuya Fukai

doi:10.1038/srep09686

Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata, Yusuke Sato, Sakurako Goto-Ito, Takeshi Uemura, Asami Maeda, Tomoko Shiroshima, Tomoyuki Yoshida, Shuya Fukai^*

^*この論文の責任著者

分子神経科学講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

43 被引用数 (Scopus)

抄録

Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

本文言語	英語
論文番号	9686
ジャーナル	Scientific Reports
巻	5
DOI	https://doi.org/10.1038/srep09686
出版ステータス	出版済み - 2015/05/19

ASJC Scopus 主題領域

一般

文献へのアクセス

10.1038/srep09686

引用スタイル

@article{6640456ebcb24253b73380b2a2630dfd,

title = "Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion",

abstract = "Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.",

author = "Atsushi Yamagata and Yusuke Sato and Sakurako Goto-Ito and Takeshi Uemura and Asami Maeda and Tomoko Shiroshima and Tomoyuki Yoshida and Shuya Fukai",

year = "2015",

month = may,

day = "19",

doi = "10.1038/srep09686",

language = "英語",

volume = "5",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

TY - JOUR

T1 - Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

AU - Yamagata, Atsushi

AU - Sato, Yusuke

AU - Goto-Ito, Sakurako

AU - Uemura, Takeshi

AU - Maeda, Asami

AU - Shiroshima, Tomoko

AU - Yoshida, Tomoyuki

AU - Fukai, Shuya

PY - 2015/5/19

Y1 - 2015/5/19

N2 - Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

AB - Selective binding between pre-And postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) . The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

UR - http://www.scopus.com/inward/record.url?scp=84930221725&partnerID=8YFLogxK

U2 - 10.1038/srep09686

DO - 10.1038/srep09686

M3 - 学術論文

C2 - 25989451

AN - SCOPUS:84930221725

SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 9686

ER -

Structure of Slitrk2-PTP complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

抄録

ASJC Scopus 主題領域

文献へのアクセス

フィンガープリント

引用スタイル