Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study

Kensuke Suzuki; Tomomi Ichikawa; Hideaki Furuse; Takeshi Tsuda; Kotaro Tokui; Yasuaki Masaki; Seisuke Okazawa; Kenta Kambara; Minehiko Inomata; Toru Yamada; Toshiro Miwa; Shoko Matsui; Tatsuhiko Kashii; Hirokazu Taniguchi; Ryuji Hayashi; Kazuyuki Tobe

doi:10.1007/s00520-014-2585-5

Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study

Kensuke Suzuki^*, Tomomi Ichikawa, Hideaki Furuse, Takeshi Tsuda, Kotaro Tokui, Yasuaki Masaki, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, Toshiro Miwa, Shoko Matsui, Tatsuhiko Kashii, Hirokazu Taniguchi, Ryuji Hayashi, Kazuyuki Tobe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with advanced lung cancer receiving chemotherapy. The objective of this study was to examine this association. Methods: In this single-center, retrospective, observational study, cortisol concentrations in 24-h pooled urine from 22 patients with advanced lung cancer were measured over 2 days. The mean concentration in each patient was compared with PS, TNM stage, and serum sodium and potassium ion levels. Results: The 24-h urine cortisol levels were higher in PS2 or PS3 cases compared to PS1 (p < 0.05) and increased proportionally with PS. Urine cortisol also increased in N2 or N3 cases compared to N1 (p < 0.01) and also increased in M1 cases (p < 0.05). Urine cortisol levels were negatively correlated with serum sodium (R = −0.49, p < 0.05) and had a tendency for a positive correlation with serum potassium (R = 0.40, p = 0.06). Conclusion: The 24-h urine cortisol level increased in patients with advanced lung cancer undergoing chemotherapy. Low serum levels of potassium and high levels of sodium may indicate relative adrenal insufficiency.

Original language	English
Pages (from-to)	2129-2133
Number of pages	5
Journal	Supportive Care in Cancer
Volume	23
Issue number	7
DOIs	https://doi.org/10.1007/s00520-014-2585-5
State	Published - 2015/12/30

Keywords

Cortisol
Lung cancer
Performance status
Urine

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00520-014-2585-5

Cite this

Suzuki, K., Ichikawa, T., Furuse, H., Tsuda, T., Tokui, K., Masaki, Y., Okazawa, S., Kambara, K., Inomata, M., Yamada, T., Miwa, T., Matsui, S., Kashii, T., Taniguchi, H., Hayashi, R., & Tobe, K. (2015). Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study. Supportive Care in Cancer, 23(7), 2129-2133. https://doi.org/10.1007/s00520-014-2585-5

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title = "Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study",

abstract = "Purpose: Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with advanced lung cancer receiving chemotherapy. The objective of this study was to examine this association. Methods: In this single-center, retrospective, observational study, cortisol concentrations in 24-h pooled urine from 22 patients with advanced lung cancer were measured over 2 days. The mean concentration in each patient was compared with PS, TNM stage, and serum sodium and potassium ion levels. Results: The 24-h urine cortisol levels were higher in PS2 or PS3 cases compared to PS1 (p < 0.05) and increased proportionally with PS. Urine cortisol also increased in N2 or N3 cases compared to N1 (p < 0.01) and also increased in M1 cases (p < 0.05). Urine cortisol levels were negatively correlated with serum sodium (R = −0.49, p < 0.05) and had a tendency for a positive correlation with serum potassium (R = 0.40, p = 0.06). Conclusion: The 24-h urine cortisol level increased in patients with advanced lung cancer undergoing chemotherapy. Low serum levels of potassium and high levels of sodium may indicate relative adrenal insufficiency.",

keywords = "Cortisol, Lung cancer, Performance status, Urine",

author = "Kensuke Suzuki and Tomomi Ichikawa and Hideaki Furuse and Takeshi Tsuda and Kotaro Tokui and Yasuaki Masaki and Seisuke Okazawa and Kenta Kambara and Minehiko Inomata and Toru Yamada and Toshiro Miwa and Shoko Matsui and Tatsuhiko Kashii and Hirokazu Taniguchi and Ryuji Hayashi and Kazuyuki Tobe",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2015",

month = dec,

day = "30",

doi = "10.1007/s00520-014-2585-5",

language = "英語",

volume = "23",

pages = "2129--2133",

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Suzuki, K, Ichikawa, T, Furuse, H, Tsuda, T, Tokui, K, Masaki, Y, Okazawa, S, Kambara, K, Inomata, M, Yamada, T, Miwa, T, Matsui, S, Kashii, T, Taniguchi, H, Hayashi, R & Tobe, K 2015, 'Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study', Supportive Care in Cancer, vol. 23, no. 7, pp. 2129-2133. https://doi.org/10.1007/s00520-014-2585-5

TY - JOUR

T1 - Relationship of the urine cortisol level with the performance status of patients with lung cancer

T2 - a retrospective study

AU - Suzuki, Kensuke

AU - Ichikawa, Tomomi

AU - Furuse, Hideaki

AU - Tsuda, Takeshi

AU - Tokui, Kotaro

AU - Masaki, Yasuaki

AU - Okazawa, Seisuke

AU - Kambara, Kenta

AU - Inomata, Minehiko

AU - Yamada, Toru

AU - Miwa, Toshiro

AU - Matsui, Shoko

AU - Kashii, Tatsuhiko

AU - Taniguchi, Hirokazu

AU - Hayashi, Ryuji

AU - Tobe, Kazuyuki

PY - 2015/12/30

Y1 - 2015/12/30

N2 - Purpose: Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with advanced lung cancer receiving chemotherapy. The objective of this study was to examine this association. Methods: In this single-center, retrospective, observational study, cortisol concentrations in 24-h pooled urine from 22 patients with advanced lung cancer were measured over 2 days. The mean concentration in each patient was compared with PS, TNM stage, and serum sodium and potassium ion levels. Results: The 24-h urine cortisol levels were higher in PS2 or PS3 cases compared to PS1 (p < 0.05) and increased proportionally with PS. Urine cortisol also increased in N2 or N3 cases compared to N1 (p < 0.01) and also increased in M1 cases (p < 0.05). Urine cortisol levels were negatively correlated with serum sodium (R = −0.49, p < 0.05) and had a tendency for a positive correlation with serum potassium (R = 0.40, p = 0.06). Conclusion: The 24-h urine cortisol level increased in patients with advanced lung cancer undergoing chemotherapy. Low serum levels of potassium and high levels of sodium may indicate relative adrenal insufficiency.

AB - Purpose: Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with advanced lung cancer receiving chemotherapy. The objective of this study was to examine this association. Methods: In this single-center, retrospective, observational study, cortisol concentrations in 24-h pooled urine from 22 patients with advanced lung cancer were measured over 2 days. The mean concentration in each patient was compared with PS, TNM stage, and serum sodium and potassium ion levels. Results: The 24-h urine cortisol levels were higher in PS2 or PS3 cases compared to PS1 (p < 0.05) and increased proportionally with PS. Urine cortisol also increased in N2 or N3 cases compared to N1 (p < 0.01) and also increased in M1 cases (p < 0.05). Urine cortisol levels were negatively correlated with serum sodium (R = −0.49, p < 0.05) and had a tendency for a positive correlation with serum potassium (R = 0.40, p = 0.06). Conclusion: The 24-h urine cortisol level increased in patients with advanced lung cancer undergoing chemotherapy. Low serum levels of potassium and high levels of sodium may indicate relative adrenal insufficiency.

KW - Cortisol

KW - Lung cancer

KW - Performance status

KW - Urine

UR - http://www.scopus.com/inward/record.url?scp=84929957075&partnerID=8YFLogxK

U2 - 10.1007/s00520-014-2585-5

DO - 10.1007/s00520-014-2585-5

M3 - 学術論文

C2 - 25547482

AN - SCOPUS:84929957075

SN - 0941-4355

VL - 23

SP - 2129

EP - 2133

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 7

ER -

Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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