Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study

Kensuke Suzuki*, Tomomi Ichikawa, Hideaki Furuse, Takeshi Tsuda, Kotaro Tokui, Yasuaki Masaki, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, Toshiro Miwa, Shoko Matsui, Tatsuhiko Kashii, Hirokazu Taniguchi, Ryuji Hayashi, Kazuyuki Tobe

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Purpose: Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with advanced lung cancer receiving chemotherapy. The objective of this study was to examine this association. Methods: In this single-center, retrospective, observational study, cortisol concentrations in 24-h pooled urine from 22 patients with advanced lung cancer were measured over 2 days. The mean concentration in each patient was compared with PS, TNM stage, and serum sodium and potassium ion levels. Results: The 24-h urine cortisol levels were higher in PS2 or PS3 cases compared to PS1 (p < 0.05) and increased proportionally with PS. Urine cortisol also increased in N2 or N3 cases compared to N1 (p < 0.01) and also increased in M1 cases (p < 0.05). Urine cortisol levels were negatively correlated with serum sodium (R = −0.49, p < 0.05) and had a tendency for a positive correlation with serum potassium (R = 0.40, p = 0.06). Conclusion: The 24-h urine cortisol level increased in patients with advanced lung cancer undergoing chemotherapy. Low serum levels of potassium and high levels of sodium may indicate relative adrenal insufficiency.

本文言語英語
ページ(範囲)2129-2133
ページ数5
ジャーナルSupportive Care in Cancer
23
7
DOI
出版ステータス出版済み - 2015/12/30

ASJC Scopus 主題領域

  • 腫瘍学

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